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Nutrition. 2018 Jun;50:8-17. doi: 10.1016/j.nut.2017.10.017. Epub 2017 Nov 28.

Do dietary patterns determine levels of vitamin B6, folate, and vitamin B12 intake and corresponding biomarkers in European adolescents? The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study.

Collaborators (210)

Moreno LA19, Fleta J19, Casajús JA19, Rodríguez G19, Tomás C19, Mesana MI19, Vicente-Rodríguez G19, Villarroya A19, Gil CM19, Ara I19, Alvira JF19, Bueno G19, Lázaro A19, Bueno O19, León JF19, Garagorri JMA19, Bueno M19, Labayen I19, Iglesia I19, Bel S19, Marco LAG19, Mouratidou T19, Santaliestra-Pasías A19, Iglesia I19, González-Gil E19, De Miguel-Etayo P19, Almárcegui CJ19, Miguel-Berges M19, Iguacel I19, Marcos A20, Wärnberg J20, Nova E20, Gómez S20, Díaz LE20, Romeo J20, Veses A20, Zapatera B20, Pozo T20, Martínez D20, Beghin L21, Libersa C21, Gottrand F21, Iliescu C21, Von Berlepsch J21, Kersting M22, Sichert-Hellert W22, Koeppen E22, Molnár D23, Erhardt E23, Csernus K23, Török K23, Bokor S23, Angster M23, Nagy E23, Kovács O23, Répasi J23, Kafatos A24, Codrington C24, Plada M24, Papadaki A24, Sarri K24, Viskadourou A24, Hatzis C24, Kiriakakis M24, Tsibinos G24, Vardavas C24, Sbokos M24, Protoyeraki E24, Fasoulaki M24, Stehle P25, Pietrzik K25, González-Gross M25, Breidenassel C25, Spinneker A25, Al-Tahan J25, Segoviano M25, Berchtold A25, Bierschbach C25, Blatzheim E25, Schuch A25, Pickert P25, Castillo MJ26, Gutiérrez Á26, Ortega FB26, Ruiz JR26, Artero EG26, España V26, Jiménez-Pavón D26, Chillón P26, Sánchez-Muñoz C26, Cuenca M26, Arcella D27, Azzini E27, Barison E27, Bevilacqua N27, Buonocore P27, Catasta G27, Censi L27, Ciarapica D27, D'Acapito P27, Ferrari M27, Galfo M27, Donne CL27, Leclercq C27, Maiani G27, Mauro B27, Mistura L27, Pasquali A27, Piccinelli R27, Polito A27, Roccaldo R27, Spada R27, Sette S27, Zaccaria M27, Scalfi L28, Vitaglione P28, Montagnese C28, De Bourdeaudhuij I29, De Henauw S29, De Vriendt T29, Maes L29, Matthys C29, Vereecken C29, de Maeyer M29, Ottevaere C29, Huybrechts I29, Widhalm K30, Phillipp K30, Dietrich S30, Manios Y31, Grammatikaki E31, Bouloubasi Z31, Cook TL31, Eleutheriou S31, Consta O31, Moschonis G31, Katsaroli I31, Kraniou G31, Papoutsou S31, Keke D31, Petraki I31, Bellou E31, Tanagra S31, Kallianoti K31, Argyropoulou D31, Tsikrika S31, Karaiskos C31, Dallongeville J32, Meirhaeghe A32, Sjöstrom M33, Ruiz JR33, Ortega FB33, Hagströmer M33, Wennlöf AH33, Hallström L33, Patterson E33, Kwak L33, Wärnberg J33, Rizzo N33, Sánchez-Molero J34, Castelló S34, Picó E34, Navarro M34, Viadel B34, Carreres JE34, Merino G34, Sanjuán R34, Lorente M34, Sánchez MJ34, Gilbert C35, Thomas S35, Allchurch E35, Burgess P35, Hall G36, Astrom A36, Sverkén A36, Broberg A36, Masson A37, Lehoux C37, Brabant P37, Pate P37, Fontaine L37, Sebok A38, Kuti T38, Hegyi A38, Maldonado C39, Llorente A39, García E40, von Fircks H41, Hallberg ML41, Messerer M41, Larsson M42, Fredriksson H42, Adamsson V42, Börjesson I42, Fernández L43, Smillie L43, Wills J43, González-Gross M44, Pedrero-Chamizo R44, Meléndez A44, Valtueña J44, Jiménez-Pavón D44, Albers U44, Benito PJ44, Lorente JJG44, Cañada D44, Urzanqui A44, Torres RM44, Navarro P44.

Author information

1
Growth, Exercise, NUtrition and Development (GENUD) Research group, Universidad de Zaragoza, Zaragoza, Spain; Instituto Agroalimentario de Aragón (IA2), Instituto de Investigación Sanitaria Aragón (IIS Aragón), Aragón, Spain; Red de Salud Materno-infantil y del Desarrollo (SAMID), Barakaldo, Spain. Electronic address: Iglesia@unizar.es.
2
Department of Public Health, Ghent University, Ghent, Belgium; International Agency for Research on Cancer (IARC), Lyon, France.
3
Growth, Exercise, NUtrition and Development (GENUD) Research group, Universidad de Zaragoza, Zaragoza, Spain.
4
Department of Preventive Medicine and Public Health, Universidad de Zaragoza, Zaragoza, Spain.
5
Growth, Exercise, NUtrition and Development (GENUD) Research group, Universidad de Zaragoza, Zaragoza, Spain; Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.
6
Growth, Exercise, NUtrition and Development (GENUD) Research group, Universidad de Zaragoza, Zaragoza, Spain; Instituto Agroalimentario de Aragón (IA2), Instituto de Investigación Sanitaria Aragón (IIS Aragón), Aragón, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERObn), Madrid, Spain.
7
Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
8
Department of Physiology, School of Medicine, University of Granada, Granada, Spain.
9
University of Crete School of Medicine, Crete, Greece.
10
Université de Lille, Clinical Investigation Centre, Lille, France.
11
Immunonutrition Research Group, Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), Madrid, Spain.
12
CREA, Research Centre for Food and Nutrition, Rome, Italy.
13
Department of Nutrition and Food Science, University of Bonn, Bonn, Germany.
14
Department of Pediatrics, University of Pécs, Pécs, Hungary.
15
Division of Clinical Nutrition and Prevention, Department of Pediatrics, Medical University of Vienna, Vienna, Austria.
16
Research Institute of Child Nutrition, Pediatric University Clinic, Ruhr University, Bochum, Germany.
17
Department of Public Health, Ghent University, Ghent, Belgium.
18
ImFINE Research Group, Department of Health and Human Performance, Universidad Politécnica de Madrid, Madrid, Spain.
19
Universidad de Zaragoza, Spain.
20
Consejo Superior de Investigaciones Científicas, Spain.
21
Université de Lille 2, France.
22
Research Institute of Child Nutrition Dortmund, Rheinische Friedrich-Wilhelms-Universität Bonn, Germany.
23
Pécsi Tudományegyetem, University of Pécs, Hungary.
24
University of Crete School of Medicine, Greece.
25
Institut für Ernährungs- und Lebensmittelwissenschaften-Ernährungphysiologie, Rheinische Friedrich Wilhelms Universität, Germany.
26
University of Granada, Spain.
27
Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione, Italy.
28
University of Napoli "Federico II" Department of Food Science, Italy.
29
Ghent University, Belgium.
30
Medical University of Vienna, Austria.
31
Harokopio University, Greece.
32
Institut Pasteur de Lille, France.
33
Karolinska Institutet, Sweden.
34
Asociación de Investigación de la Industria Agroalimentaria, Spain.
35
Campden BRI, United Kingdom.
36
SIK-Institutet foer Livsmedel och Bioteknik, Sweden.
37
Meurice Recherche & Development asbl, Belgium.
38
Campden & Chorleywood Food Development Institute, Hungary.
39
Productos Aditivos SA, Spain.
40
Cárnicas Serrano SL, Spain.
41
Cederroth International AB, Sweden.
42
Lantmännen Food R&D, Sweden.
43
European Food Information Council, Belgium.
44
Universidad Politécnica de Madrid, Spain.

Abstract

OBJECTIVES:

To determine dietary patterns (DPs) and explain the highest variance of vitamin B6, folate, and B12 intake and related concentrations among European adolescents.

METHODS:

A total of 2173 adolescents who participated in the Healthy Lifestyle in Europe by Nutrition in Adolescence study met the eligibility criteria for the vitamin B intake analysis (46% boys) and 586 adolescents for the biomarkers analysis (47% boys). Two non-consecutive, 24-h, dietary recalls were used to assess the mean intakes. Concentrations were measured by chromatography and immunoassay testing. A reduced rank regression was applied to elucidate the combined effect of food intake of vitamin B and related concentrations.

RESULTS:

The identified DPs (one per vitamin B intake and biomarker and by sex) explained a variability between 34.2% and 23.7% of the vitamin B intake and between 17.2% and 7% of the biomarkers. In the reduced rank regression models, fish, eggs, cheese, whole milk and buttermilk intakes were loaded positively for vitamin B intake in both sexes; however, soft drinks and chocolate were loaded negatively. For the biomarkers, a higher variability was observed in the patterns in terms of food loads such as alcoholic drinks, sugars, and soft drinks. Some food items were loaded differently between intakes and biomarkers such as fish products, which was loaded positively for intakes but negatively for plasma folate in girls.

CONCLUSIONS:

The identified DPs explained up to 34.2% and 17.2% of the variability of the vitamin B intake and plasma concentrations, respectively, in European adolescents. Further studies are needed to elucidate the factors that determine such patterns.

KEYWORDS:

Adolescents; Dietary patterns; Europe; Reduced rank regression; Vitamin B

PMID:
29518603
DOI:
10.1016/j.nut.2017.10.017
[Indexed for MEDLINE]

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