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Food Chem Toxicol. 2018 May;115:136-147. doi: 10.1016/j.fct.2018.03.003. Epub 2018 Mar 5.

Pharmacokinetics of [14C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction.

Author information

1
Department of Nutrition and Dietetics, Oregon State University, Corvallis, OR, USA; Superfund Research Program, Oregon State University, Corvallis, OR, USA.
2
Superfund Research Program, Oregon State University, Corvallis, OR, USA; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA.
3
Superfund Research Program, Oregon State University, Corvallis, OR, USA; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA; Linus Pauling Institute, Oregon State University, Corvallis, OR, USA.
4
Linus Pauling Institute, Oregon State University, Corvallis, OR, USA.
5
Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, USA.
6
Center for Accelerator Mass Spectrometry, Lawrence Livermore National Laboratory, Livermore, CA, USA.
7
Confederated Tribes of the Umatilla Indian Reservation, Nixyáawii Governance Center, Pendelton, OR, USA.
8
Superfund Research Program, Oregon State University, Corvallis, OR, USA; Chemical Biology and Exposure Science, Pacific Northwest National Laboratory, Richland, WA, USA.
9
Superfund Research Program, Oregon State University, Corvallis, OR, USA; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA; Linus Pauling Institute, Oregon State University, Corvallis, OR, USA. Electronic address: david.williams@oregonstate.edu.

Abstract

Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is a known human carcinogen. In non-smoking adults greater than 95% of BaP exposure is through diet. The carcinogenicity of BaP is utilized by the U.S. EPA to assess relative potency of complex PAH mixtures. PAH relative potency factors (RPFs, BaP = 1) are determined from high dose animal data. We employed accelerator mass spectrometry (AMS) to determine pharmacokinetics of [14C]-BaP in humans following dosing with 46 ng (an order of magnitude lower than human dietary daily exposure and million-fold lower than animal cancer models). To assess the impact of co-administration of food with a complex PAH mixture, humans were dosed with 46 ng of [14C]-BaP with or without smoked salmon. Subjects were asked to avoid high BaP-containing diets and a 3-day dietary questionnaire given to assess dietary exposure prior to dosing and three days post-dosing with [14C]-BaP. Co-administration of smoked salmon, containing a complex mixture of PAHs with an RPF of 460 ng BaPeq, reduced and delayed absorption. Administration of canned commercial salmon, containing very low amounts of PAHs, showed the impacts on pharmacokinetics were not due to high amounts of PAHs but rather a food matrix effect.

KEYWORDS:

Accelerator mass spectrometry; Benzo[a]pyrene; Dietary polycyclic aromatic hydrocarbons; Pharmacokinetics

PMID:
29518434
PMCID:
PMC5935529
[Available on 2019-05-01]
DOI:
10.1016/j.fct.2018.03.003
[Indexed for MEDLINE]

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