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Breast J. 2018 Jul;24(4):509-518. doi: 10.1111/tbj.13003. Epub 2018 Mar 8.

Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain.

Author information

1
Department of Epidemiology and Evaluation, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
2
Research Network on Health Services in Chronic Diseases (REDISSEC), Barcelona, Spain.
3
Department of Health, Catalan Cancer Plan, Barcelona, Spain.
4
Preventive Medicine and Epidemiology Department, Hospital Clinic, Barcelona, Spain.
5
Epidemiology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
6
Department of Obstetrics and Gynecology, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
7
Breast Cancer Screening Program of Tarragona, The Foundation League for the Research and Prevention of Cancer, Tarragona, Spain.
8
General Directorate of Public Health, Government of Cantabria, Santander, Spain.
9
Clinical Epidemiology and Cancer Screening, Parc Taulí University Hospital, Sabadell, Spain.
10
Cancer Prevention and Monitoring Program, Catalan Institute of Oncology, Barcelona, Spain.
11
Department of Oncology, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
12
Breast Cancer Screening Program, Principality of Asturias, Oviedo, Spain.
13
Department of Pathological Anatomy, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
14
Radiology Department, Hospital de Santa Caterina, Girona, Spain.
15
Department of Image Diagnostics, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.

Abstract

Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69 years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1 years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2 cm (OR = 1.46; 95%CI = 1.03-2.08), metastatic positive (OR = 2.66; 95%CI = 1.21-5.86), and with a high Ki-67 proliferation rate (OR = 1.93; 95%CI = 1.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.

KEYWORDS:

benign breast disease; breast neoplasm; prognostic factors

PMID:
29517151
DOI:
10.1111/tbj.13003
[Indexed for MEDLINE]

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