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Open Forum Infect Dis. 2018 Jan 30;5(3):ofy029. doi: 10.1093/ofid/ofy029. eCollection 2018 Mar.

Time Course of C-Reactive Protein and Procalcitonin Levels During the Treatment of Acute Bacterial Skin Infections.

Author information

1
Department of Medicine, Denver Health, Denver, Colorado.
2
Division of Infectious Diseases, Denver Health, Denver, Colorado.
3
Department of Patient Safety and Quality, Denver Health, Denver, Colorado.
4
Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado.
5
Division of Infectious Diseases, University of Colorado School of Medicine, Aurora, Colorado.
6
Department of Emergency Medicine, Denver Health, Denver, Colorado.
7
Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, Colorado.
8
Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, Colorado.
9
Denver Public Health, Denver Health, Denver, Colorado.

Abstract

In a pilot study of 22 patients with an acute bacterial skin infection, serum levels of C-reactive protein and procalcitonin tended to be elevated at presentation and declined within 3-5 days of treatment. Further study of a biomarker-guided treatment strategy to reduce antibiotic overuse in skin infections is warranted.

KEYWORDS:

C-reactive protein; acute bacterial skin and skin structure infection; antibiotic stewardship; biomarker; procalcitonin; skin and soft tissue infection

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