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Sci Rep. 2018 Mar 7;8(1):4118. doi: 10.1038/s41598-018-22494-4.

Emergence of Different Recombinant Porcine Reproductive and Respiratory Syndrome Viruses, China.

Liu Y1,2,3, Li J1, Yang J1, Zeng H1, Guo L1, Ren S1, Sun W1, Chen Z1, Cong X1, Shi J1, Chen L1, Du Y1,4, Li J1,4, Wang J5,6,7, Wu J8,9,10, Yu J11.

Author information

1
Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan, 250100, China.
2
School of Life Sciences, Shandong University, Jinan, 250100, China.
3
Biotechnology Research Center, Shandong Academy of Agricultural Sciences, Jinan, 250100, China.
4
School of Life Sciences, Shandong Normal University, Jinan, Jinan, 250014, China.
5
Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan, 250100, China. wangjb@saas.ac.cn.
6
School of Life Sciences, Shandong University, Jinan, 250100, China. wangjb@saas.ac.cn.
7
School of Life Sciences, Shandong Normal University, Jinan, Jinan, 250014, China. wangjb@saas.ac.cn.
8
Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan, 250100, China. wujiaqiang2000@sina.com.
9
School of Life Sciences, Shandong University, Jinan, 250100, China. wujiaqiang2000@sina.com.
10
School of Life Sciences, Shandong Normal University, Jinan, Jinan, 250014, China. wujiaqiang2000@sina.com.
11
Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan, 250100, China. yujiang_2213@163.com.

Abstract

Epidemiological investigations were conducted on recently emerging porcine reproductive and respiratory syndrome virus (PRRSV) strains in Shandong province in 2014-2015. The proportion of the NADC30 strain identified by ORF7 sequence alignment has been gradually increasing. Three emerging PRRSV strains were successfully isolated, and the complete genomic sequences were determined. Our results indicate the importance of recombinant strains in Shandong province, China. There was a varied degree of recombination of two or three strains (classical, HP-PRRSV and/or NADC30). Moreover, the recombination strains affected the pathogenicity of newly emerged strains.

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