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J Infect Dis. 2018 Jun 20;218(2):259-264. doi: 10.1093/infdis/jiy121.

Genetic Diversity of Cryptosporidium hominis in a Bangladeshi Community as Revealed by Whole-Genome Sequencing.

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Department of Medicine, University of Virginia, Charlottesville.
Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom.
International Centre for Diarrhoeal Disease Research, Bangladesh.
Department of Statistics, University of Virginia, Charlottesville.
Cryptosporidium Reference Unit, Public Health Wales Microbiology, Singleton Hospital.
Swansea University Medical School, Singleton Park, Swansea, United Kingdom.
Department of Public Health Sciences, University of Virginia, Charlottesville.


We studied the genetic diversity of Cryptosporidium hominis infections in slum-dwelling infants from Dhaka over a 2-year period. Cryptosporidium hominis infections were common during the monsoon, and were genetically diverse as measured by gp60 genotyping and whole-genome resequencing. Recombination in the parasite was evidenced by the decay of linkage disequilibrium in the genome over <300 bp. Regions of the genome with high levels of polymorphism were also identified. Yet to be determined is if genomic diversity is responsible in part for the high rate of reinfection, seasonality, and varied clinical presentations of cryptosporidiosis in this population.

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