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Mol Med Rep. 2018 May;17(5):6909-6913. doi: 10.3892/mmr.2018.8684. Epub 2018 Mar 6.

Investigation of the expressions of MMPs and TIMPs between isogeneic and allogeneic rat aortic transplantation.

Author information

1
Department of Hepatobiliary Surgery, People's Hospital of Zhengzhou, Southern Medical University, Zhengzhou, Henan 450003, P.R. China.
2
Department of Hepatobiliary Surgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China.

Abstract

The present study investigated the effects of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) in transplantation-associated arteriosclerosis by observing their expression in transplanted aortas in rats. Allogenic and isogenic abdominal aortic transplantations were performed and grafts were removed from the recipients at the designated time points (day 7, 14, 28 and 56 post transplantation). Hematoxylin and eosin staining, immunohistochemistry, immunofluorescence and western blot analysis were used to evaluate the grafts. Significant proliferation of the intima was observed in the allogenic transplantation groups (P<0.05). The expressions of MMPs and TIMPs in the allografts were significantly increased compared with the isografts, and the suppression of MMP2 in allografts reduced injury after transplantation. The present study concluded that the imbalance of MMPs and TIMPs led to the disturbance of synthesis and the degradation of the extracellular matrix and it may represent a key cause of chronic rejection.

PMID:
29512764
DOI:
10.3892/mmr.2018.8684
[Indexed for MEDLINE]

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