Format

Send to

Choose Destination
Mol Biol (Mosk). 2018 Jan-Feb;52(1):112-119. doi: 7868/S0026898418010159.

[Model of the Complex of the Human Glycyl-tRNA Synthetase Anticodon-Binding Domain with IRES I Fragment].

[Article in Russian]

Author information

1
Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290 Russia.
2
alik@vega.protres.ru.

Abstract

The currently available structural information is insufficient for a detailed analysis of interactions between human glycyl-tRNA synthetase (GARS) and enterovirus IRESs. At the same time, this information is required in order to understand how this IRES trans-acting factor (ITAF) functions during viral mRNA translation, which is in turn crucial for the development of direct-action antiviral agents. In this paper, a theoretical model of the complex between a cadicivirus A IRES fragment and the anticodon-binding domain of human GARS is constructed using molecular dynamics simulation based on all of the available structural and biochemical data. The proposed model enables the structural interpretation of the previously obtained biochemical data.

KEYWORDS:

CDV; IRES; IRES I; cadicivirus A; enteroviruses; glycyl-tRNA synthetase; picornaviruses; poliovirus; tRNA^(Gly); translation initiation

PMID:
29512643
DOI:
7868/S0026898418010159
Free full text

Supplemental Content

Full text links

Icon for Molekuliarnaia biologiia
Loading ...
Support Center