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Indian J Med Res. 2017 Nov;146(5):642-645. doi: 10.4103/ijmr.IJMR_468_15.

Seroprevalence & changing trends of transfusion-transmitted infections amongst blood donors in a Regional Blood Transfusion Centre in north India.

Author information

1
Department of Pathology, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi, India.

Abstract

Background & objectives:

Transfusion-transmitted infections (TTIs) are the major problem associated with blood transfusion. Accurate estimates of risk of TTIs are essential for monitoring the safety of blood supply. The present study was undertaken to determine the percentage of voluntary donors (VDs) and replacement donors (RDs) and also, to estimate and compare the seroprevalence and changing trends of TTIs amongst VDs and RDs in a regional blood transfusion centre in north India.

Methods:

This retrospective study was based on the records of all voluntary and replacement donations which were collected from January 2008 to December 2014 in a Regional Blood Transfusion Centre placed in a tertiary care hospital in Delhi, India.

Results:

Of the total 220,482 donations, 163,540 (74.17%) were voluntary and 56,942 (25.83%) were replacement donation. The overall seroprevalence of human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), syphilis and malaria were 0.32, 1.61, 0.73, 1.62 and 0.06 per cent, respectively. Furthermore, the TTIs were more frequently encountered in RDs in comparison to VDs.

Interpretation & conclusions:

The increase in public awareness regarding voluntary blood donation, meticulous donor screening, counselling and use of highly sensitive tests can help in reducing the risk of TTIs.

KEYWORDS:

Hepatitis B virus - hepatitis C virus - human immunodeficiency virus - replacement donors - syphilis and malaria - transfusion-transmitted infections - voluntary donors

PMID:
29512607
PMCID:
PMC5861476
DOI:
10.4103/ijmr.IJMR_468_15
[Indexed for MEDLINE]
Free PMC Article

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