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Acta Microbiol Immunol Hung. 2018 Aug 1;65(3):309-315. doi: 10.1556/030.65.2018.021. Epub 2018 Mar 7.

Value of the eazyplex® CSF direct assay in rapid diagnosis of invasive meningococcal disease - Case report.

Author information

1
1 Institute of Medical Microbiology, Jena University Hospital , Jena, Germany.
2
2 Present address: Institute of Clinical Chemistry and Laboratory Medicine, Jena University Hospital , Jena, Germany.
3
3 Hans Berger Department of Neurology, Jena University Hospital , Jena, Germany.
4
4 Institute of Hygiene and Microbiology, German Reference Laboratory for Meningococci and Haemophilus influenzae (NRZMHi), University of Würzburg , Würzburg, Germany.
5
5 Institute of Pathology, Jena University Hospital , Jena, Germany.

Abstract

There is a need for easy-to-use molecular assays for diagnosis of invasive meningococcal disease. Here, we report the rapid identification of Neisseria meningitidis in a cerebrospinal fluid sample from a patient with purulent meningitis using a commercially available loop-mediated isothermal amplification assay, resulting in a prompt de-escalation of the initial empiric antibiotic therapy.

KEYWORDS:

LAMP; Neisseria meningitidis; invasive meningococcal disease

PMID:
29512393
DOI:
10.1556/030.65.2018.021
[Indexed for MEDLINE]

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