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FEBS Open Bio. 2018 Jan 31;8(3):435-441. doi: 10.1002/2211-5463.12383. eCollection 2018 Mar.

Serum amyloid A1 (SAA1) protein in human colostrum.

Author information

1
Department of Biological Chemistry Johns Hopkins University School of Medicine Baltimore MD USA.
2
Department of Medicine Johns Hopkins University School of Medicine Baltimore MD USA.
3
Department of Obstetrics and Gynecology Johns Hopkins University School of Medicine Baltimore MD USA.
4
Institute for Basic Biomedical Sciences Johns Hopkins University School of Medicine Baltimore MD USA.
5
Department of Pathology University of Nebraska Medical Center Omaha NE USA.

Abstract

Proteins of the serum amyloid A (SAA) family have been remarkably conserved in evolution. Their biologic function(s) are not fully defined but they are likely to be a part of primordial host defense. We have detected a ∼ 12-kDa protein reacting with antibodies against serum amyloid A (SAA) in human colostrum by western blotting. Mass spectrometry identified the reactive species as SAA1, previously identified as a prominent member of the acute-phase response in serum. Our finding SAA1 in human colostrum contrasts with bovine, caprine and ovine colostrum where a species corresponding to putative SAA3 is uniformly present. SAA1 protein in human colostrum presumably contributes to neonatal protection.

KEYWORDS:

acute‐phase; amyloid; colostrum; serum amyloid A

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