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J Clin Med Res. 2018 Apr;10(4):294-301. doi: 10.14740/jocmr3153w. Epub 2018 Feb 18.

Primary Small Intestinal Angiosarcoma: Epidemiology, Diagnosis and Treatment.

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University of Toledo Medical Center, Toledo, OH 43614, USA.
These authors contributed equally.
Raritan Bay Medical Center, Perth Amboy, NJ 08861, USA.
School of Public Health, Shandong University, Jinan 250012, China.
Saint Peter's University Hospital, New Brunswick, NJ 08901, USA.
Department of Radiation Oncology and Shandong Province Key Laboratory of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, China.
Shandong Academy of Medical Sciences, Jinan 250117, China.
Department of Neurology, Brigham and Women's Hospital, 60 Fenwood Road, Boston, MA 02115, USA.


Angiosarcoma is an aggressive mesenchymal sarcoma of endothelial cell origin with high mortality. Its occurrence in the small intestine is exceedingly low. In addition to the rarity of small intestine angiosarcoma, the nonspecific early clinical symptoms obscure the suspicion of such tumors and thereby delay the diagnosis. In a hope to improve the knowledge of this rare but fatal neoplasm, we report one case of angiosarcoma of duodenum and jejunum in a 73-year-old man. Furthermore, we summarize and analyze the common clinical features, tumor markers, treatment, and survival of previous reported cases of this malignancy. Small bowel angiosarcoma occurs more often in men than women (1.6:1). The median age at diagnosis is 68.5 years. The overall median survival time is 150 days; the median survival time in female (300 days) is longer than that of male patients (120 days). Von Willebrand factor (vWF), CD31, CD34, vimentin, and Ulex europaeus agglutinin 1 appear to be the most useful markers for the diagnosis. The majority of the patients underwent surgical resection alone or surgery with subsequent chemotherapy. The patients treated with surgery plus chemotherapy survive longer than those underwent surgical resection only (median 420 days, n = 7 vs. 96.5 days, n = 26, respectively; P = 0.0275). Further studies of more cases are needed for a better understanding of this rare entity, as well as the development of effective strategies for prevention, early diagnosis, and treatment.


Angiosarcoma; Diagnosis; Small intestine; Survival; Treatment

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