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Nat Commun. 2018 Mar 6;9(1):813. doi: 10.1038/s41467-018-03206-y.

Convergent genomic signatures of domestication in sheep and goats.

Author information

1
Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, LECA, F-38000, Grenoble, France.
2
School of Biosciences, Cardiff University, Museum Avenue, CF10 3AX, Cardiff, Wales, UK.
3
European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
4
GenPhySE, INRA, INPT, ENVT, Université de Toulouse, 31326, Castanet-Tolosan, France.
5
CEFE-CNRS, UMR 5175, 1919 route de Mende, 34293, Montpellier 05, France.
6
Institut National de la Recherche Agronomique Maroc (INRA-Maroc), Centre Régional de Beni Mellal, Beni Mellal, 23000, Morocco.
7
Centre for GeoGenetics, Natural History Museum of Denmark, Øster Voldade 5-7, 1350K, Copenhagen, Denmark.
8
PTP Science Park, Bioinformatics Unit, Via Einstein-Loc. Cascina Codazza, 26900, Lodi, Italy.
9
CNR-IBBA, Via Bassini 15, 20133, Milano, Italy.
10
Istituto di Zootecnica, Facoltà di Scienze Agrarie, Alimentari e Ambientali, Università Cattolica del S. Cuore, via Emilia Parmense n. 84, 29122, Piacenza (PC), Italy.
11
BioDNA - Centro di Ricerca sulla Biodiversità e DNA Antico, Facoltà di Scienze Agrarie, Alimentarie e Ambientali, Università Cattolica del S. Cuore, via Emilia Parmense n. 84, 29122, Piacenza (PC), Italy.
12
Department of Environmental Sciences, Faculty of Natural Resources and Marine Sciences, Tarbiat Modares University, 46417-76489, Noor, Mazandaran, Iran.
13
CEA - Institut de biologie François-Jacob, Genoscope, 2 rue Gaston Crémieux, 91057, Evry, France.
14
Laboratory of Geographic Information Systems (LASIG), School of Architecture, Civil and Environmental Engineering (ENAC), Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland.
15
AIA Associazione Italiana Allevatori, 00161, Roma, Italy.
16
Laboratoire d'Anthropologie Moléculaire et d'Imagerie de Synthèse, CNRS UMR 5288, Université de Toulouse, Université Paul Sabatier, 31000, Toulouse, France.
17
Department of Environmental Sci, Gorgan University of Agricultural Sciences & Natural Resources, 41996-13776, Gorgan, Iran.
18
Environmental Sciences Department, Natural Resources Faculty, University of Guilan, 49138-15749, Guilan, Iran.
19
CNRS, UMR 8030, CP5706, Evry, France.
20
Université d'Evry, UMR 8030, CP5706, Evry, France.
21
CSIRO Agriculture, 306 Carmody Road, St. Lucia, QLD, 4067, Australia.
22
Institut National de la Recherche Agronomique Maroc (INRA-Maroc), Centre Régional d'Errachidia, Errachidia, 52000, Morocco.
23
Sustainable Places Research Institute, Cardiff University, 33 Park Place, CF10 3BA, Cardiff, Wales, UK.
24
Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, LECA, F-38000, Grenoble, France. francois.pompanon@univ-grenoble-alpes.fr.

Abstract

The evolutionary basis of domestication has been a longstanding question and its genetic architecture is becoming more tractable as more domestic species become genome-enabled. Before becoming established worldwide, sheep and goats were domesticated in the fertile crescent 10,500 years before present (YBP) where their wild relatives remain. Here we sequence the genomes of wild Asiatic mouflon and Bezoar ibex in the sheep and goat domestication center and compare their genomes with that of domestics from local, traditional, and improved breeds. Among the genomic regions carrying selective sweeps differentiating domestic breeds from wild populations, which are associated among others to genes involved in nervous system, immunity and productivity traits, 20 are common to Capra and Ovis. The patterns of selection vary between species, suggesting that while common targets of selection related to domestication and improvement exist, different solutions have arisen to achieve similar phenotypic end-points within these closely related livestock species.

PMID:
29511174
PMCID:
PMC5840369
DOI:
10.1038/s41467-018-03206-y
[Indexed for MEDLINE]
Free PMC Article

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