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Nutrients. 2018 Mar 3;10(3). pii: E301. doi: 10.3390/nu10030301.

Gastrointestinal Tolerance and Glycemic Response of Isomaltooligosaccharides in Healthy Adults.

Author information

1
Global Nutrition R&D, Ingredion Incorporated, 10 Finderne Ave, Bridgewater, NJ 08807, USA. vishnupriya.gourineni@ingredion.com.
2
Global Nutrition R&D, Ingredion Incorporated, 10 Finderne Ave, Bridgewater, NJ 08807, USA. maria.stewart@ingredion.com.
3
Global Sweeteners R&D, Ingredion Incorporated, 10 Finderne Ave, Bridgewater, NJ 08807, USA. didem.icoz@ingredion.com.
4
Global Nutrition R&D, Ingredion Incorporated, 10 Finderne Ave, Bridgewater, NJ 08807, USA. paul.zimmer@bayer.com.

Abstract

Ingredients delivering functional and nutritional benefits are of interest to food manufacturers. Isomaltooligosaccharides (IMOs) which serve as alternate sweeteners fit into this category. IMOs are a mixture of α-(1 → 6) and α-(1 → 4)-linked glucose oligomers, synthesized by an enzymatic reaction from starch (corn, tapioca). The aim of this study was to evaluate the fermentability and glycemic response of IMO in a healthy population. Two randomized, double-blind, placebo-controlled, cross-over human studies were conducted. In the first study (n = 26), participants' breath hydrogen over 24 h, gastrointestinal tolerance, and glycemic and insulinemic response to BIOLIGOTM IL5040 isomaltooligosaccharide were measured. In another study (n = 10), participants' two-hour post-prandial glycemic response to BIOLIGOTM IL5040 isomaltooligosaccharide and BIOLIGOTM IL7010 isomaltooligosaccharide was measured compared to dextrose (control). The IMOs differed in the composition of mono and di-saccharide sugars. IMO syrup dose was matched for 50 g of total carbohydrates and was consumed by mixing in water (237 mL/8 oz.). Mean composite gastrointestinal score was not significantly different (p = 0.322) between the control (1.42) and IMO (1.38). Lack of difference in glycemic response (p = 0.662), with no impact on breath hydrogen (24 h; p = 0.319) and intestinal tolerance, demonstrates that IMO is digestible and can be used to replace sugars in product formulations.

KEYWORDS:

breath hydrogen; glycemic response; isomaltooligosaccharides; tolerance

PMID:
29510490
PMCID:
PMC5872719
DOI:
10.3390/nu10030301
[Indexed for MEDLINE]
Free PMC Article

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