Format

Send to

Choose Destination
Eur J Pharm Sci. 2018 May 30;117:279-289. doi: 10.1016/j.ejps.2018.03.004. Epub 2018 Mar 3.

The role of lactose carrier on the powder behavior and aerodynamic performance of bosentan microparticles for dry powder inhalation.

Author information

1
College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 28160, Republic of Korea.
2
College of Pharmacy, Woosuk University, Wanju 55338, Republic of Korea.
3
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju 52828, Republic of Korea.
4
Department of Physical Medicine and Rehabilitation, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
5
School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
6
Department of Pharmaceutical Engineering, Cheongju University, Cheongju 28503, Republic of Korea. Electronic address: pharmengin@cju.ac.kr.
7
College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 28160, Republic of Korea. Electronic address: cwpark@cbnu.ac.kr.

Abstract

In this study, we prepared carrier-based formulations for dry powder inhalers by mixing bosentan microparticles with carrier, prepared in three separate types of lactose. Spray-dried, milled and sieved lactose resulted in formulations with various shapes, surface morphology and particle size distributions. In the spray-dried lactose, the micronized bosentan particles were trapped and strongly interlocked in the rugged surface of spray-dried lactose, whereas in the milled and sieved lactose they exhibited lower binding affinity onto the smooth surface of carrier. In all of the carrier-based formulations, the flow properties were improved compared with bosentan microparticles alone, in the following order spray-dried, sieved and milled lactose. The aerodynamic characteristics of each were evaluated by particle image velocimetry and Andersen cascade impactorâ„¢. Depending on the lactose carrier type, particle dispersion showed different flow characteristics. In the spray-dried lactose, the formulation was dispersed fast in the only frontal direction, while the milled and sieved lactose formulations formed a relatively slower S-shaped and fountain-shaped flow stream, respectively. In addition, milled and sieved lactose formulations showed that the drug particles were readily liberated from the lactose carrier, and demonstrated significantly higher aerosol performance than spray-dried lactose.

KEYWORDS:

Bosentan; Carrier; Dry powder inhalers; Lactose; Particle image velocimetry

PMID:
29510172
DOI:
10.1016/j.ejps.2018.03.004
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center