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Aust Dent J. 2018 Jun;63(2):231-241. doi: 10.1111/adj.12605. Epub 2018 Apr 19.

Response of periodontium to mineral trioxide aggregate and Biodentine: a pilot histological study on humans.

Author information

1
Private Practice, Cuneo, Italy.
2
Department of Medical, Oral and Biotechnological Sciences, Chieti-Pescara University 'G. D'Annunzio', Chieti, Italy.
3
University of Valencia, Valencia, Spain.
4
Universidad Catolica de San Antonio de Murcia (UCAM), Murcia, Spain.

Abstract

BACKGROUND:

The aim of this study was to investigate for the first time the histological response of human periodontium to mineral trioxide aggregate (MTA) and Biodentine.

METHODS:

Six patients scheduled for implant full-arch rehabilitation were randomly assigned to one of the two test groups: MTA or Biodentine treatment. For each patient, two teeth scheduled for strategic extraction were randomly assigned either to the test or to the control treatment. A lateral perforation was drilled on the root and either repaired with MTA/Biodentine or filled with gutta-percha(control). Three months later, the teeth were extracted along with the coronal third of the alveolar bone and a portion of gingival tissue, while performing implant placement, and processed for histological analysis.

RESULTS:

Biodentine resulted in less extrusion into the periodontal environment. All the materials showed good biocompatibility. A new mineralized cementum-like tissue incorporating periodontal fibres was visible in all cases treated with MTA. A small amount of new mineralized tissue was found in two Biodentine cases but not in control cases. Biodentine resulted in less damage to the periodontal ligament.

CONCLUSIONS:

Bioactivity and biocompatibility of MTA were confirmed in human models. Biodentine proved to be biocompatible, but it seems not to induce cementum regeneration.

KEYWORDS:

Biodentine; histology; human model; mineral trioxide aggregate; root perforation

PMID:
29509293
DOI:
10.1111/adj.12605

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