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Int Urogynecol J. 2018 Aug;29(8):1093-1099. doi: 10.1007/s00192-018-3587-5. Epub 2018 Mar 6.

A generic health-related quality of life instrument for assessing pelvic organ prolapse surgery: correlation with condition-specific outcome measures.

Author information

1
Stockholm Urogynecological Clinic, Stockholm, Sweden.
2
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
3
Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
4
Division of Obstetrics and Gynecology, Department of Clinical Sciences, Karolinska Institutet Danderyd Hospital, S-182 88 Danderyd, Stockholm, Sweden.
5
Division of Obstetrics and Gynecology, Department of Clinical Sciences, Karolinska Institutet Danderyd Hospital, S-182 88 Danderyd, Stockholm, Sweden. edward.morcos@sll.se.

Abstract

INTRODUCTION AND HYPOTHESIS:

The aim of this study was to investigate the use of a generic and globally accessible instrument for assessing health-related quality of life (HR-QoL) in pelvic organ prolapse (POP) surgery.

METHODS:

In a prospective multicenter setting, 207 women underwent surgery for apical prolapse [stage ≥2, Pelvic Organ Prolapse Quantificcation (POP-Q) system] with or without anterior wall defect. Demographic and surgical characteristics were collected before surgery. Results of the 15-dimensional (15D) instrument and condition-specific pelvic floor symptoms as assessed using the Pelvic Floor Distress Inventory questionnaire (PFDI-20), including its subscales Pelvic Organ Prolapse Distress Inventory-6 (POPDI-6), Colorectal-Anal Distress Inventory-8 (CRADI-8), and Urinary Distress Inventory-6 (UDI-6), were assessed preoperatively and 2 months and 1 year after surgery.

RESULTS:

HR-QoL as estimated by 15D was improved 1 year after surgery (p < 0.001). Prolapse-related 15D profile-index measures (excretion, discomfort, sexual activity, distress, and mobility) were significantly improved after surgery (p < 0.05-0.001). Significant inverse associations were detected between increased 15D scores and a decrease in PFDI-20 and subscale scores (p < 0.001), indicating improvements on both instruments.

CONCLUSIONS:

Generic HR-QoL as estimated by 15D improved significantly after apical POP surgery and correlated with improvements of condition-specific outcome measures. These results suggest that a comprehensive evaluation of global HR-QoL is valid in assessing pelvic reconstructive surgery and may provide novel and important insights into previously understudied areas, such as cost-utility and cost-effectiveness analysis after urogynecological surgery.

KEYWORDS:

15D; Pelvic floor condition-specific outcome measures; Quality of life; Urogynecological surgery

PMID:
29508043
DOI:
10.1007/s00192-018-3587-5
[Indexed for MEDLINE]

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