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Epidemiol Prev. 2018 Jan-Feb;42(1):20-33. doi: 10.19191/EP18.1.P020.012.

[Residential cohort study on mortality and hospitalization in Viggiano and Grumento Nova Municipalities in the framework of HIA in Val d'Agri (Basilicata Region, Southern Italy)].

[Article in Italian]

Author information

1
Istituto di fisiologia clinica, Unità di epidemiologia ambientale e registri di patologia, Consiglio nazionale delle ricerche, Pisa.
2
Istituto di fisiologia clinica, Unità di epidemiologia ambientale e registri di patologia, Consiglio nazionale delle ricerche, Pisa. fabriepi@ifc.cnr.it.
3
Dipartimento di epidemiologia del Servizio sanitario regionale del Lazio, ASL Roma 1.
4
Istituto di scienze dell'atmosfera e del clima, Consiglio nazionale delle ricerche.
5
Dipartimento di biologia, Università degli Studi di Bari.
6
Responsabile scientifico. Istituto di fisiologia clinica del CNR (IFC-CNR).
7
Coordinamento. Istituto di fisiologia clinica del CNR (IFC-CNR).
8
Istituto di fisiologia clinica del CNR (IFC-CNR).
9
Fondazione toscana Gabriele Monasterio (CNR-Regione Toscana).
10
Istituto di scienze dell'atmosfera e del clima del CNR (ISAC-CNR)(LE).
11
Istituto di scienze dell'atmosfera e del clima del CNR (ISAC-CNR)(BO).
12
Istituto di scienze dell'atmosfera e del clima del CNR (ISAC-CNR)(TO).
13
Istituto per lo studio degli ecosistemi del CNR (ISE-CNR).
14
Dipartimento di epidemiologia del Servizio sanitario regionale del Lazio.

Abstract

OBJECTIVES:

to evaluate the associations among the emissions produced by "Centro olio Val d'Agri" (COVA), with mortality and hospitalization of residents in the Viggiano and Grumento Nova Municipalities, located in Val d'Agri (Basilicata Region, Southern Italy).

DESIGN:

residential cohort study.

SETTINGS AND PARTICIPANTS:

Lagrangians dispersion models to estimate the level of exposure at the address of residence to NOX concentrations as tracers of COVA emissions. Based on the tertile of NOX distribution, individual exposure was classified and a Cox model analysis was performed (hazard ratio, HR, trend with relative 95%CI). The association among exposure to NOX and the cohort mortality/hospitalization was evaluated considering age, socioeconomic status, and distance from the high traffic density road. The cohort included 6,795 residents (73,270 person-years) in the period 2000-2014.

MAIN OUTCOME MEASURES:

causes of mortality and hospitalization due to cardio-respiratory diseases, recognised as associated to air pollution, with medium-short latency induction period, consistent with the period of operation at the COVA.

RESULTS:

increasing trends were observed on three exposure classes for mortality due to circulatory system diseases (HR trend: 1.19; 95%CI 1.02-1.39), stronger considering women (HR trend: 1.19; 95%CI 1.02-1.39). From hospitalizations results, an increased risk emerges for respiratory diseases (HR trend: 1.12; 95%CI 1.01-1.25) and, for women, for diseases of the circulatory system (HR trend: 1.19; 95%CI 1.03-1.38), for ischemic diseases (HR trend: 1.33; 95%CI 1.02-1.74) and respiratory diseases (HR trend: 1.22; 95%CI 1.03-1.46).

CONCLUSIONS:

the excesses of mortality and hospitalization emerged in areas most exposed to pollutants of industrial origin are relevant for preventive actions. It is recommended to define and implement a surveillance system for the entire resident population based on indicators of environmental pollution and related health outcomes on the basis of the scientific literature and the results achieved by the present study.

PMID:
29506358
DOI:
10.19191/EP18.1.P020.012
[Indexed for MEDLINE]
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