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Exp Clin Endocrinol Diabetes. 2019 May;127(5):320-325. doi: 10.1055/s-0043-122881. Epub 2018 Mar 5.

The Beneficial Effects of Trimetazidine on Reperfusion-Induced Arrhythmia in Diabetic Rats.

Author information

1
Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahwaz Iran.
2
Ahvaz Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahwaz Iran.
3
Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahwaz Iran.
4
Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahwaz, Iran.
#
Contributed equally

Abstract

Trimetazidine (TMZ), as an anti-ischemic drug, plays a critical role in protecting against cardiovascular complications induced by diabetes. This study was therefore aimed to evaluate the protective effects of TMZ on reperfusion-induced arrhythmias in the diabetic rats. Male Sprague-Dawley rats (250±20 g) were randomly assigned to four (n=8): control rats (C), alloxan induced diabetic rats (D), diabetic rats treated with TMZ (10 mg/kg, D+T10), diabetic rats treated with TMZ (30 mg/kg, D+T30). TMZ was treated orally once daily for 8 weeks. Diabetes was induced by a single intraperitoneal injection of alloxan (120 mg/kg). Ischemia-reperfusion (I/R) was carried out via 30 min of ischemia and following120-min reperfusion. The magnitude and score of arrhythmia, the left ventricular function, infarct size, lactate dehydrogenase (LDH), myocardial creatine kinase (CK-MB) and troponin (cTnI) were measured. The findings were evaluated by two-way repeated measures and one-way ANOVA followed by LSD post hoc test and Fisher's exact test for incidence percentage. The duration, incidence and score of arrhythmia (p<0.001), infarct size (p<0.01) were significantly increased, the cardiac contractility (±dp/dt), LDH, CK-MB (p<0.001) and cTnI (p<0.05) were significantly decreased in the diabetic rats in comparison with the control group. However, treatment with TMZ in the diabetic rats was significantly improved the duration (p<0.001), incidence and score of arrhythmia,±dp/dt LDH, CK-MB, cTnI (p<0.05) and infarct size (p<0.01) in comparison with the untreated diabetic group. The present study indicates anti-arrhythmic effect of TMZ in reducing arrhythmias induced by reperfusion in the diabetic rats.

PMID:
29506311
DOI:
10.1055/s-0043-122881
[Indexed for MEDLINE]

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