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Rheumatology (Oxford). 2018 May 1;57(suppl_4):iv75-iv87. doi: 10.1093/rheumatology/key005.

Which supplements can I recommend to my osteoarthritis patients?

Author information

Rheumatology Department, Royal North Shore Hospital, St Leonards, Sydney, NSW, Australia.
Institute of Bone and Joint Research, the Kolling Institute, The University of Sydney, Sydney, NSW, Australia.
Physiotherapy Department, Royal North Shore Hospital, Sydney, NSW, Australia.
Faculty of Pharmacy and Centre for Education and Research in Ageing, The University of Sydney and Concord Hospital, Sydney, NSW, Australia.
Department of Veterinary Preclinical Sciences, School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK.
Arthritis Research UK Centre for Sport, Exercise and Osteoarthritis, Queen's Medical Centre, Nottingham, UK.


OA is a chronic and disabling joint disease with limited evidence-based pharmacological treatment options available that improve outcomes for patients safely. Faced with few effective pharmacological treatments, the use has grown of dietary supplements and complementary medicines for symptomatic relief among people living with OA. The aim of this review is to provide a summary of existing evidence and recommendations supporting the use of supplements for OA. Systematic reviews and randomized controlled trials investigating oral supplements for treating OA were identified. Limited research evidence supports recommendations for the oral use of Boswellia serrata extract and Pycnogenol, curcumin and methylsulfonylmethane in people with OA despite the poor quality of the available studies. Few studies adequately reported possible adverse effects related to supplementation, although the products were generally recognized as safe. Further high quality trials are needed to improve the strength of evidence to support this recommendation and better guide optimal treatment of people living with OA.

[Indexed for MEDLINE]

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