Format

Send to

Choose Destination
Aesthet Surg J. 2018 Jan 30. doi: 10.1093/asj/sjy019. [Epub ahead of print]

Safety and Effectiveness of Repeat Treatment With VYC-15L for Lip and Perioral Enhancement: Results From a Prospective Multicenter Study.

Author information

1
David Geffen/UCLA School of Medicine, Los Angeles, CA.
2
Dermatology, University of South Florida, Tampa, FL.
3
Allergan plc (Irvine, CA) at the time of manuscript preparation.
4
Department of Dermatology, University of Maryland School of Medicine, Baltimore, MD.
5
Department of Dermatology, Saint Louis University, St. Louis, MO.
6
Centre for Laser and Facial Surgery, Vanderbilt University School of Medicine, Nashville, TN.
7
Clinical Development at Allergan plc.

Abstract

Background:

VYC-15L (Juvéderm Volbella XC) is a non-animal crosslinked hyaluronic acid (HA) gel with lidocaine.

Objective:

To evaluate safety and effectiveness of repeat treatment with VYC-15L administered 1 year after treatment for lip and perioral enhancement.

Methods:

In this prospective multicenter study, 124 subjects with minimal, mild, or moderate lip fullness on the validated 5-point Allergan Lip Fullness Scale (LFS) who received initial/touch-up treatment with VYC-15L received repeat treatment with VYC-15L 1 year after initial treatment. Effectiveness endpoints included LFS responder rates (≥1-point improvement from baseline) and scores on the FACE-Q Satisfaction With Lips and Appraisal of Lip Lines scales at 1 month after repeat treatment. Subjects completed safety diaries for 30 days after repeat treatment.

Results:

LFS responder rates were 86.2%, 80.3%, and 61.8% at months 1 and 3 and 1 year, respectively, after initial/touch-up treatment. The responder rate improved to 94.3% 1 month after repeat treatment with VYC-15L and required less median volume vs initial/touchup treatment (1.5 vs 2.6 mL). FACE-Q scores doubled from baseline at 3 months, remained high through 1 year, and doubled from baseline after repeat treatment. At 1 month after repeat treatment, 96.7% and 89.3% of subjects showed improvement over baseline in FACE-Q Satisfaction With Lips and Appraisal of Lip Lines, respectively. Severe injection site responses were less frequent after repeat treatment than initial/touch-up treatment.

Conclusion:

Repeat treatment with VYC-15L at 1 year was safe and effective for lip and perioral enhancement, and required less product volume to achieve similar effectiveness to initial/touch-up treatment.

PMID:
29506034
DOI:
10.1093/asj/sjy019

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center