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Trends Cell Biol. 2018 May;28(5):405-415. doi: 10.1016/j.tcb.2018.01.009. Epub 2018 Mar 1.

Clustering on Membranes: Fluctuations and More.

Author information

1
Institut Curie, PSL Research University, Cellular and Chemical Biology unit, INSERM U 1143, CNRS UMR 3666, 26 rue d'Ulm, 75248 Paris Cedex 05, France. Electronic address: ludger.johannes@curie.fr.
2
Center for Biomembrane Physics (MEMPHYS), Department of Physics, Chemistry and Pharmacy (FKF), University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark.
3
Center for Biomembrane Physics (MEMPHYS), Department of Physics, Chemistry and Pharmacy (FKF), University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark. Electronic address: ipsen@memphys.sdu.dk.
4
Blue Brain Project, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. Electronic address: julian.shillcock@epfl.ch.

Abstract

Clustering of extracellular ligands and proteins on the plasma membrane is required to perform specific cellular functions, such as signaling and endocytosis. Attractive forces that originate in perturbations of the membrane's physical properties contribute to this clustering, in addition to direct protein-protein interactions. However, these membrane-mediated forces have not all been equally considered, despite their importance. In this review, we describe how line tension, lipid depletion, and membrane curvature contribute to membrane-mediated clustering. Additional attractive forces that arise from protein-induced perturbation of a membrane's fluctuations are also described. This review aims to provide a survey of the current understanding of membrane-mediated clustering and how this supports precise biological functions.

PMID:
29502867
DOI:
10.1016/j.tcb.2018.01.009
[Indexed for MEDLINE]

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