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Asian-Australas J Anim Sci. 2018 Mar;31(3):429-438. doi: 10.5713/ajas.17.0733. Epub 2018 Feb 21.

Effects of Rubus coreanus byproducts on intestinal microbiota and the immune modulation.

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Department of Animal Resources Technology, Gyeongnam National University of Science and Technology, Jinju 52725, Korea.
Department of Animal Science, Chonnam National University, Gwangju 61186, Korea.
Department of Animal Science & Biotechnology, Gyeongnam National University of Science and Technology, Jinju 52725, Korea.
Department of Animal Science and Technology, Sunchon National University, Sunchon 57922, Korea.
Dasan Genetics, Namwon 55716, Korea.
Jeonbuk Institute for Bioindustry, Jeonju 54810, Korea.
Berry & Biofood Research Institute, Gochang 56417, Korea.
Department of Life Science, Silla University, Busan 46958, Korea.



Although the efficacy of Rubus coreanus (RC) byproducts as a feed additive has been recognized, its effects on intestinal microorganisms and the immune system are still unknown.


Six-week-old male rats were treated with 0.5% RC (T1), 1.0% RC (T2), and 1.5% RC (T3) for 4 weeks.


We found that treatment with RC byproducts significantly increased the daily gain of body weight and feed intake. Treg-cell differentiation was enhanced in the mesenteric lymph nodes and spleen from the rats fed with RC byproducts. Illumina sequencing showed that bacteria in the phylum Firmicutes decreased and while those in the phylum Bacteroidetes increased in RC-treated groups. Particularly, the pathogenic microorganisms in the family Peptococcaceae decreased, and the non-pathogenic families Lachnospiraceae and S24-7 increased. Quantitative polymerase chain reaction analysis showed that the RC byproducts increased the lactic acid bacteria Bifidobacterium spp., Oscillospira spp., Leuconostoc citreum, and Weissella cibaria in a concentration-dependent manner.


RC byproducts may be effective in immunomodulation by affecting intestinal microorganisms.


Galectin-9; Illumina Sequencing; Immune Modulation; Intestinal Microbiota; Rubus coreanus; Th1/Th2 Balance

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