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Cold Spring Harb Perspect Med. 2018 Sep 4;8(9). pii: a031344. doi: 10.1101/cshperspect.a031344.

Neural Regulation of Bone and Bone Marrow.

Author information

1
Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York 10461.
2
Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461.
3
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461.

Abstract

Bones provide both skeletal scaffolding and space for hematopoiesis in its marrow. Previous work has shown that these functions were tightly regulated by the nervous system. The central and peripheral nervous systems tightly regulate compact bone remodeling, its metabolism, and hematopoietic homeostasis in the bone marrow (BM). Accumulating evidence indicates that the nervous system, which fine-tunes inflammatory responses and alterations in neural functions, may regulate autoimmune diseases. Neural signals also influence the progression of hematological malignancies such as acute and chronic myeloid leukemias. Here, we review the interplay of the nervous system with bone, BM, and immunity, and discuss future challenges to target hematological diseases through modulation of activity of the nervous system.

PMID:
29500307
PMCID:
PMC6119651
DOI:
10.1101/cshperspect.a031344
[Indexed for MEDLINE]
Free PMC Article

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