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J Craniomaxillofac Surg. 2018 Apr;46(4):688-696. doi: 10.1016/j.jcms.2018.01.006. Epub 2018 Feb 2.

Preclinical randomized controlled trial of bilateral discectomy versus bilateral discopexy in Black Merino sheep temporomandibular joint: TEMPOJIMS - Phase 1- histologic, imaging and body weight results.

Author information

1
Faculty of Medicine of Lisbon University, Av. Prof, Egas Moniz, 1649-035 Lisboa, Portugal; Centre for Rapid and Sustainable Product Development, Polytechnic Institute of Leiria, Portugal, Rua de Portugal, Zona Industrial, Marinha Grande, 2430-028, Marinha Grande, Portugal. Electronic address: david.serrano.angelo@gmail.com.
2
Centre for Rapid and Sustainable Product Development, Polytechnic Institute of Leiria, Portugal, Rua de Portugal, Zona Industrial, Marinha Grande, 2430-028, Marinha Grande, Portugal. Electronic address: pedro.morouco@ipleiria.pt.
3
Infanta Cristina Hospital, Faculty of Medicina, University of Extremadura, Av. Elvas, S/N, 06006 Badajoz, Spain. Electronic address: fmonje@oralmaxilofacial.com.
4
Faculty of Medicine of Coimbra University, Portugal. Electronic address: lisetemonico@gmail.com.
5
Infanta Cristina Hospital, Faculty of Medicina, University of Extremadura, Av. Elvas, S/N, 06006 Badajoz, Spain. Electronic address: Raulmaxilo@gmail.com.
6
Faculty of Medicine of Lisbon University, Av. Prof, Egas Moniz, 1649-035 Lisboa, Portugal. Electronic address: ritafsousa1@gmail.com.
7
Faculty of Medicine of Lisbon University, Av. Prof, Egas Moniz, 1649-035 Lisboa, Portugal. Electronic address: lia_neto@yahoo.com.
8
Faculty of Medicine of Lisbon University, Av. Prof, Egas Moniz, 1649-035 Lisboa, Portugal. Electronic address: maria_caldeira@hotmail.com.
9
Kolling Institute, Institute of Bone and Joint Research, University of Sydney, Australia. Electronic address: mobsmith@sydney.edu.au.
10
Kolling Institute, Institute of Bone and Joint Research, University of Sydney, Australia. Electronic address: susan.smith@sydney.edu.au.
11
Faculty of Medicine of Coimbra University, Portugal. Electronic address: d.sanz@hotmail.com.
12
Faculty of Veterinary Medicine of Lisbon University, Portugal. Electronic address: faas@outlook.pt.
13
Faculty of Veterinary Medicine of Lisbon University, Portugal. Electronic address: mpinho@fmv.ulisboa.pt.
14
Faculty of Veterinary Medicine of Lisbon University, Portugal. Electronic address: belmira@fmv.ulisboa.pt.
15
Instituto Nacional de Investigação Agrária e Veterinária (INIAVIP), Portugal. Electronic address: sandracavaco1@gmail.com.
16
Centre for Rapid and Sustainable Product Development, Polytechnic Institute of Leiria, Portugal, Rua de Portugal, Zona Industrial, Marinha Grande, 2430-028, Marinha Grande, Portugal. Electronic address: carla.moura@ipleiria.pt.
17
Centre for Rapid and Sustainable Product Development, Polytechnic Institute of Leiria, Portugal, Rua de Portugal, Zona Industrial, Marinha Grande, 2430-028, Marinha Grande, Portugal. Electronic address: nuno.alves@ipleiria.pt.
18
Faculty of Medicine of Lisbon University, Av. Prof, Egas Moniz, 1649-035 Lisboa, Portugal. Electronic address: fjsalvado2002@yahoo.com.
19
Kolling Institute, Institute of Bone and Joint Research, University of Sydney, Australia. Electronic address: christopher.little@sydney.edu.au.

Abstract

INTRODUCTION:

The role of temporomandibular joint (TMJ) surgery is not well defined due to a lack of quality randomized controlled clinical trials, comparing different TMJ surgical treatments with medical and placebo interventions. The temporomandibular joint interposal study (TEMPOJIMS) is a rigorous preclinical trial divided in 2 phases. In phase 1 the authors investigated the role of the TMJ disc and in phase 2 the authors evaluated 3 different interposal materials. The present work of TEMPOJIMS - phase 1, aims to evaluate histopathologic and imaging changes of bilateral discectomy and discopexy in Black Merino sheep TMJ, using a high-quality trial following the ARRIVE guidelines.

MATERIAL AND METHODS:

This randomized, blinded and controlled preclinical trial was conducted in 9 Black Merino sheep to investigate histopathologic (primary outcome), imaging and body weight (secondary outcomes) changes after bilateral discectomy, discopexy and sham surgery.

RESULTS:

Significant changes were noticed in discectomy group, both in imaging and histopathologic analyses. Body weight changes were most pronounced in the discectomy group in the first 4 months after surgery with recovery to baseline weight 6 months after surgery. Discopexy induced nonsignificant changes in histopathologic, imaging and body weight analyses.

CONCLUSIONS:

This study reinforces the importance of developing an effective interposal material to substitute the TMJ disc and the need to explore the molecular mechanisms that underlie TMJ cartilage degeneration. The study design proposed in TEMPOJIMS represents an important progress towards future rigorous TMJ investigations.

KEYWORDS:

Preclinical study; TMJ disc; TMJ discectomy; TMJ discopexy; TMJ histology; TMJ imaging

PMID:
29500103
DOI:
10.1016/j.jcms.2018.01.006
[Indexed for MEDLINE]

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