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Mol Cell. 2018 Mar 1;69(5):723-725. doi: 10.1016/j.molcel.2018.02.013.

Uneven Braking Spins RNA Polymerase into a Pause.

Author information

1
Department of Microbiology and The Center for RNA Biology, The Ohio State University, Columbus, OH, USA. Electronic address: artsimovitch.1@osu.edu.
2
Department of Biochemistry, University of Turku, Turku, Finland.

Abstract

In this issue of Molecular Cell, Guo et al. (2018) and Kang et al. (2018) report structures of paused transcription complexes in which asynchronous translocation inhibits nucleotide addition, allowing for global rearrangements in RNA polymerase stabilized by RNA hairpin and NusA.

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