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Br J Nutr. 2018 Feb;119(4):381-390. doi: 10.1017/S0007114517003774.

The effect of short-term coenzyme Q10 supplementation and pre-cooling strategy on cardiac damage markers in elite swimmers.

Author information

1
1Department of Exercise Physiology and Corrective Movement, Sport Sciences Faculty,Urmia University, Urmia,57561-51818,Iran.
2
2Department of Internal Medicine and Clinical Pathology, Veterinary Medicine Faculty,Urmia University,Urmia, 57561-51818,Iran.
3
3Department of Food Hygiene and Quality Control, Veterinary Science Faculty,Bu-Ali Sina University,Hamedan, 65178-38695,Iran.

Abstract

Strenuous physical exercise and hyperthermia may paradoxically induce oxidative stress and adverse effects on myocardial function. The purpose of this study was to investigate the effect of 14-d coenzyme Q10 (CoQ10) supplementation and pre-cooling on serum creatine kinase-MB (CK-MB), cardiac Troponin I (cTnI), myoglobin (Mb), lactate dehydrogenase (LD), total antioxidant capacity (TAC), lipid peroxidation (LPO) and CoQ10 concentration in elite swimmers. In total, thirty-six healthy males (mean age 17 (sd 1) years) were randomly selected and divided into four groups of supplementation, supplementation with pre-cooling, pre-cooling and control. During an eighteen-session protocol in the morning and evening, subjects attended speed and endurance swimming training sessions for 5 km in each session. Blood sampling was done before (two stages) and after (two stages) administration of CoQ10 and pre-cooling. ANCOVA and repeated measurement tests with Bonferroni post hoc test were used for the statistical analysis of the data. There was no significant statistical difference among groups for the levels of CK-MB, cTnI, Mb, LD, TAC, LPO and CoQ10 at the presampling (stages 1 and 2) (P>0·05). However, pre-cooling and control groups show a significant increase in the levels of CK-MB, cTnI, Mb, LD and LPO compared with the supplementation and supplementation with pre-cooling groups in the post-sampling (stages 1 and 2) (P<0·05), except for the TAC and CoQ10. Consequently, CoQ10 supplementation prevents adverse changes of myocardial damage and oxidative stress during swimming competition phase. Meanwhile, the pre-cooling strategy individually has no desired effect on the levels of CK-MB, cTnI, Mb, LD, LPO, TAC and CoQ10.

KEYWORDS:

CK-MB creatine kinase-MB; CoQ10 coenzyme Q10 ; LD lactate dehydrogenase; LPO lipid peroxidation; Mb myoglobin; ROS reactive oxygen species; TAC total antioxidant capacity; THR target heart rate; cTnI cardiac Troponin I; Cardiac damage markers; Coenzyme Q10 ; Elite swimmers; Heavy training; Pre-cooling

PMID:
29498347
DOI:
10.1017/S0007114517003774
[Indexed for MEDLINE]

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