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Appl Microbiol Biotechnol. 2018 Apr;102(8):3439-3451. doi: 10.1007/s00253-018-8803-1. Epub 2018 Mar 1.

Genome-scale biological models for industrial microbial systems.

Xu N1,2,3, Ye C1,4,3, Liu L5,6,7.

Author information

1
State Key Laboratory of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu, 214122, China.
2
College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, Jiangsu, 225009, China.
3
The Laboratory of Food Microbial-Manufacturing Engineering, Jiangnan University, Wuxi, 214122, China.
4
Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu, 214122, China.
5
State Key Laboratory of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu, 214122, China. mingll@jiangnan.edu.cn.
6
Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu, 214122, China. mingll@jiangnan.edu.cn.
7
The Laboratory of Food Microbial-Manufacturing Engineering, Jiangnan University, Wuxi, 214122, China. mingll@jiangnan.edu.cn.

Abstract

The primary aims and challenges associated with microbial fermentation include achieving faster cell growth, higher productivity, and more robust production processes. Genome-scale biological models, predicting the formation of an interaction among genetic materials, enzymes, and metabolites, constitute a systematic and comprehensive platform to analyze and optimize the microbial growth and production of biological products. Genome-scale biological models can help optimize microbial growth-associated traits by simulating biomass formation, predicting growth rates, and identifying the requirements for cell growth. With regard to microbial product biosynthesis, genome-scale biological models can be used to design product biosynthetic pathways, accelerate production efficiency, and reduce metabolic side effects, leading to improved production performance. The present review discusses the development of microbial genome-scale biological models since their emergence and emphasizes their pertinent application in improving industrial microbial fermentation of biological products.

KEYWORDS:

Cell growth; Genome-scale modeling; Microbial biosynthesis; Systematic metabolic engineering

PMID:
29497793
DOI:
10.1007/s00253-018-8803-1
[Indexed for MEDLINE]

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