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Clin Kidney J. 2012 Apr;5(2):153-154. doi: 10.1093/ndtplus/sfr160. Epub 2012 Feb 22.

Renal ablation using bilateral ureteral ligation for nephrotic syndrome due to renal amyloidosis.

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Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN.
Division of Transplantation Surgery, Mayo Clinic, Rochester, MN.


Nephrotic syndrome is common in immunoglobulin light chain amyloidosis (AL). In patients who do not achieve renal recovery, renal ablation has been reported for intractable proteinuria. We describe a patient with renal-limited AL who failed therapy and developed disabling proteinuria. He underwent laparoscopic ligation of the native ureters. Post-operatively, blood pressure improved. Hemodialysis was initiated. We conclude that bilateral ureteral ligation is a novel and minimally invasive method of renal ablation and may be considered for patients with refractory nephrotic syndrome.


amyloidosis; nephrotic; ureteral ligation

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