Format

Send to

Choose Destination
J Cell Sci. 2018 Mar 1;131(5). pii: jcs216150. doi: 10.1242/jcs.216150.

Meeting Report - proteostasis in Ericeira.

Author information

1
Membrane Traffic Lab, Instituto Gulbenkian de Ciência (IGC), Oeiras, Portugal cadrain@igc.gulbenkian.pt sivankorenblit@gmail.com domingp@itqb.unl.pt.
2
The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel cadrain@igc.gulbenkian.pt sivankorenblit@gmail.com domingp@itqb.unl.pt.
3
Instituto de Tecnologia Química e Biológica (ITQB-NOVA), Oeiras, Portugal cadrain@igc.gulbenkian.pt sivankorenblit@gmail.com domingp@itqb.unl.pt.

Abstract

It was a sunny Ericeira, in Portugal, that received the participants of the EMBO Workshop on Proteostasis, from 17 to 21 November 2017. Most participants gave talks or presented posters concerning their most recent research results, and lively scientific discussions occurred against the backdrop of the beautiful Atlantic Ocean.Proteostasis is the portmanteau of the words protein and homeostasis, and it refers to the biological mechanisms controlling the biogenesis, folding, trafficking and degradation of proteins in cells. An imbalance in proteostasis can lead to the accumulation of misfolded proteins or excessive protein degradation, and is associated with many human diseases. A wide variety of research approaches are used to identify the mechanisms that regulate proteostasis, typically involving different model organisms (yeast, invertebrates or mammalian systems) and different methodologies (genetics, biochemistry, biophysics, structural biology, cell biology and organismal biology). Around 140 researchers in the proteostasis field met in the Hotel Vila Galé, Ericeira, Portugal for the EMBO Workshop in Proteostasis, organized by Pedro Domingos (ITQB-NOVA, Oeiras, Portugal) and Colin Adrain (IGC, Oeiras, Portugal). In this report, we attempt to review and integrate the ideas that emerged at the workshop. Owing to space restrictions, we could not cover all talks or posters and we apologize to the colleagues whose presentations could not be discussed.

PMID:
29496898
DOI:
10.1242/jcs.216150
Free full text

Conflict of interest statement

Competing interestsThe authors declare no competing or financial interests.

Publication type

Publication type

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center