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Fitoterapia. 2018 Jun;127:245-251. doi: 10.1016/j.fitote.2018.02.028. Epub 2018 Feb 26.

Cassaine diterpenoids from the seeds of Erythrophleum fordii and their cytotoxic activities.

Author information

1
Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
2
School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong 999077, China.
3
School of Stomatology and Medicine, Foshan University, Foshan 528000, China. Electronic address: tieniu29@gmail.com.
4
School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong 999077, China; School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen 518057, China. Electronic address: csxu@cuhk.edu.hk.
5
Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China. Electronic address: thytian@jnu.edu.cn.

Abstract

Six new cassaine diterpenoids (1, 3-7), along with three known ones (2, 8-9) were isolated from the seeds of Erythrophleum fordii. Their structures were elucidated by extensive spectroscopic methods and acid hydrolysis. Compound 2 was tested to be the most potent one and showed more sensitive activities on MCF-7 and A549 cancer cells with IC50 values of 3.66 ± 1.20 and 2.87 ± 0.46 μM, respectively. Furthermore, compound 2 reduced the number of cell colonies significantly in a dose-dependent manner in the colony formation assay and triggered apoptosis of MCF-7 cell.

KEYWORDS:

Cassaine diterpenoid; Cytotoxic activities; Erythrophleum fordii

PMID:
29496564
DOI:
10.1016/j.fitote.2018.02.028
[Indexed for MEDLINE]

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