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Int J Mol Sci. 2018 Feb 28;19(3). pii: E694. doi: 10.3390/ijms19030694.

Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses.

Author information

1
Research Group on Quality, Safety and Bioactivity of Plant Foods, CEBAS-CSIC, P.O. Box 164, Campus de Espinardo, 30100 Murcia, Spain. mtconesa@cebas.csic.es.
2
Quadram Institute Bioscience, Norwich Research Park, Norwich NR4 7UA, UK. Karen.Chambers@quadram.ac.uk.
3
Human Nutrition, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G31 2ER, UK. emilie.combetAspray@glasgow.ac.uk.
4
Biotechnology and Nutrition, Department of Food Technology, ESA, Polytechnic Institute of Santarem, 2001-904 Santarém, Portugal. paula.pinto@esa.ipsantarem.pt.
5
Molecular Nutrition Health Laboratory, iBET/ITQB, 2780-157 Oeiras, Portugal. paula.pinto@esa.ipsantarem.pt.
6
Biomarkers and Nutrimetabolomic Laboratory, Department of Nutrition, Food Sciences and Gastronomy, XaRTA, INSA, Faculty of Pharmacy and Food Sciencies, University of Barcelona, 08028 Barcelona, Spain. margarcia@ub.edu.
7
CIBER de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, 08028 Barcelona, Spain. margarcia@ub.edu.
8
Biomarkers and Nutrimetabolomic Laboratory, Department of Nutrition, Food Sciences and Gastronomy, XaRTA, INSA, Faculty of Pharmacy and Food Sciencies, University of Barcelona, 08028 Barcelona, Spain. candres@ub.edu.
9
CIBER de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, 08028 Barcelona, Spain. candres@ub.edu.
10
Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), Jose Antonio Novais 10, 28040 Madrid, Spain. s.depascualteresa@csic.es.
11
Human Nutrition Unit, Department of Food Drug, University of Parma, 43125 Parma, Italy. pedromiguel.menaparreno@unipr.it.
12
Institute for Medical Research, University of Belgrade, 11000 Belgrade, Serbia. a.konicristic@leeds.ac.uk.
13
School of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, UK. a.konicristic@leeds.ac.uk.
14
Quadram Institute Bioscience, Norwich Research Park, Norwich NR4 7UA, UK. wendy.hollands@quadram.ac.uk.
15
Quadram Institute Bioscience, Norwich Research Park, Norwich NR4 7UA, UK. paul.kroon@quadram.ac.uk.
16
Department of Nutritional Sciences, School of Life Course Sciences, Faculty of Life Science and Medicine, King's College London, London SE1 9NH, UK. ana.rodriguez-mateos@kcl.ac.uk.
17
Department of Nutritional Sciences, School of Life Course Sciences, Faculty of Life Science and Medicine, King's College London, London SE1 9NH, UK. g.istas@kcl.ac.uk.
18
Laboratory of Hygiene and Environmental Protection, Department of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece. ckontogi@med.duth.gr.
19
Teagasc Food Research Centre Ashtown, D15 KN3K Dublin, Ireland. dilip.rai@teagasc.ie.
20
UCD Institute of Food and Health, University College Dublin, Dublin 4, Ireland. eileen.gibney@ucd.ie.
21
INRA, Human Nutrition Unit, UCA, CRNH Auvergne, F-63000 Clermont-Ferrand, France. christine.morand@inra.fr.
22
Research Group on Quality, Safety and Bioactivity of Plant Foods, CEBAS-CSIC, P.O. Box 164, Campus de Espinardo, 30100 Murcia, Spain. jcespin@cebas.csic.es.
23
Research Group on Quality, Safety and Bioactivity of Plant Foods, CEBAS-CSIC, P.O. Box 164, Campus de Espinardo, 30100 Murcia, Spain. agsarrias@cebas.csic.es.

Abstract

Understanding interindividual variability in response to dietary polyphenols remains essential to elucidate their effects on cardiometabolic disease development. A meta-analysis of 128 randomized clinical trials was conducted to investigate the effects of berries and red grapes/wine as sources of anthocyanins and of nuts and pomegranate as sources of ellagitannins on a range of cardiometabolic risk biomarkers. The potential influence of various demographic and lifestyle factors on the variability in the response to these products were explored. Both anthocyanin- and ellagitannin-containing products reduced total-cholesterol with nuts and berries yielding more significant effects than pomegranate and grapes. Blood pressure was significantly reduced by the two main sources of anthocyanins, berries and red grapes/wine, whereas waist circumference, LDL-cholesterol, triglycerides, and glucose were most significantly lowered by the ellagitannin-products, particularly nuts. Additionally, we found an indication of a small increase in HDL-cholesterol most significant with nuts and, in flow-mediated dilation by nuts and berries. Most of these effects were detected in obese/overweight people but we found limited or non-evidence in normoweight individuals or of the influence of sex or smoking status. The effects of other factors, i.e., habitual diet, health status or country where the study was conducted, were inconsistent and require further investigation.

KEYWORDS:

anthocyanins; berries; cardiometabolic disorders; ellagitannins; interindividual variability; meta-analysis; nuts; pomegranate; red grapes; red wine

PMID:
29495642
PMCID:
PMC5877555
DOI:
10.3390/ijms19030694
[Indexed for MEDLINE]
Free PMC Article

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