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Viruses. 2018 Feb 28;10(3). pii: E102. doi: 10.3390/v10030102.

Detection and Characterization of Homologues of Human Hepatitis Viruses and Pegiviruses in Rodents and Bats in Vietnam.

Author information

1
Nuffield Department of Medicine, University of Oxford, Oxford OX1 3SY, UK. dung.nguyen@ndm.ox.ac.uk.
2
Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City 700000, Vietnam. cuongnv@oucru.org.
3
Nuffield Department of Medicine, University of Oxford, Oxford OX1 3SY, UK. david.bonsall@ndm.ox.ac.uk.
4
Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City 700000, Vietnam. tuent@oucru.org.
5
Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City 700000, Vietnam. jcarrique-mas@oucru.org.
6
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Oxford University, Oxford OX3 7FZ, UK. jcarrique-mas@oucru.org.
7
Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City 700000, Vietnam. anhph@oucru.org.
8
Fondation Mérieux, Centre International de Recherche en Infectiologie (CIRI), 69365 Lyon CEDEX 07, France. juliet.bryant@fondation-merieux.org.
9
Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City 700000, Vietnam. gthwaites@oucru.org.
10
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Oxford University, Oxford OX3 7FZ, UK. gthwaites@oucru.org.
11
Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City 700000, Vietnam. sbaker@oucru.org.
12
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Oxford University, Oxford OX3 7FZ, UK. sbaker@oucru.org.
13
The London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK. sbaker@oucru.org.
14
Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh EH9 3FL, UK. mark.woolhouse@ed.ac.uk.
15
Nuffield Department of Medicine, University of Oxford, Oxford OX1 3SY, UK. peter.simmonds@ndm.ox.ac.uk.

Abstract

Rodents and bats are now widely recognised as important sources of zoonotic virus infections in other mammals, including humans. Numerous surveys have expanded our knowledge of diverse viruses in a range of rodent and bat species, including their origins, evolution, and range of hosts. In this study of pegivirus and human hepatitis-related viruses, liver and serum samples from Vietnamese rodents and bats were examined by PCR and sequencing. Nucleic acids homologous to human hepatitis B, C, E viruses were detected in liver samples of 2 (1.3%) of 157 bats, 38 (8.1%), and 14 (3%) of 470 rodents, respectively. Hepacivirus-like viruses were frequently detected (42.7%) in the bamboo rat, Rhizomys pruinosus, while pegivirus RNA was only evident in 2 (0.3%) of 638 rodent serum samples. Complete or near-complete genome sequences of HBV, HEV and pegivirus homologues closely resembled those previously reported from rodents and bats. However, complete coding region sequences of the rodent hepacivirus-like viruses substantially diverged from all of the currently classified variants and potentially represent a new species in the Hepacivirus genus. Of the viruses identified, their routes of transmission and potential to establish zoonoses remain to be determined.

KEYWORDS:

Vietnam; bats; hepatitis viruses; homologues; pegiviruses; rodents

PMID:
29495551
PMCID:
PMC5869495
DOI:
10.3390/v10030102
[Indexed for MEDLINE]
Free PMC Article

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