Format

Send to

Choose Destination
Int J Mol Sci. 2018 Feb 25;19(3). pii: E650. doi: 10.3390/ijms19030650.

Messenger RNA Life-Cycle in Cancer Cells: Emerging Role of Conventional and Non-Conventional RNA-Binding Proteins?

Coppin L1,2,3, Leclerc J4,5,6, Vincent A7,8,9, Porchet N10,11,12, Pigny P13,14,15.

Author information

1
University of Lille, UMR-S 1172-JPARC-Jean-Pierre Aubert Research Center, F-59000 Lille, France. lucie.coppin@inserm.fr.
2
Inserm, UMR-S 1172, Team "Mucins, Epithelial Differentiation and Carcinogenesis", F-59000 Lille, Frances. lucie.coppin@inserm.fr.
3
CHU Lille, Service de Biochimie "Hormonologie, Métabolisme-Nutrition, Oncologie", F-59000 Lille, France. lucie.coppin@inserm.fr.
4
University of Lille, UMR-S 1172-JPARC-Jean-Pierre Aubert Research Center, F-59000 Lille, France. julie.leclerc@inserm.fr.
5
Inserm, UMR-S 1172, Team "Mucins, Epithelial Differentiation and Carcinogenesis", F-59000 Lille, Frances. julie.leclerc@inserm.fr.
6
CHU Lille, Service de Biochimie "Hormonologie, Métabolisme-Nutrition, Oncologie", F-59000 Lille, France. julie.leclerc@inserm.fr.
7
University of Lille, UMR-S 1172-JPARC-Jean-Pierre Aubert Research Center, F-59000 Lille, France. audrey.vincent@inserm.fr.
8
Inserm, UMR-S 1172, Team "Mucins, Epithelial Differentiation and Carcinogenesis", F-59000 Lille, Frances. audrey.vincent@inserm.fr.
9
CHU Lille, Service de Biochimie "Hormonologie, Métabolisme-Nutrition, Oncologie", F-59000 Lille, France. audrey.vincent@inserm.fr.
10
University of Lille, UMR-S 1172-JPARC-Jean-Pierre Aubert Research Center, F-59000 Lille, France. nicole.porchet.blg@gmail.com.
11
Inserm, UMR-S 1172, Team "Mucins, Epithelial Differentiation and Carcinogenesis", F-59000 Lille, Frances. nicole.porchet.blg@gmail.com.
12
CHU Lille, Service de Biochimie "Hormonologie, Métabolisme-Nutrition, Oncologie", F-59000 Lille, France. nicole.porchet.blg@gmail.com.
13
University of Lille, UMR-S 1172-JPARC-Jean-Pierre Aubert Research Center, F-59000 Lille, France. pascal.pigny@inserm.fr.
14
Inserm, UMR-S 1172, Team "Mucins, Epithelial Differentiation and Carcinogenesis", F-59000 Lille, Frances. pascal.pigny@inserm.fr.
15
CHU Lille, Service de Biochimie "Hormonologie, Métabolisme-Nutrition, Oncologie", F-59000 Lille, France. pascal.pigny@inserm.fr.

Abstract

Functional specialization of cells and tissues in metazoans require specific gene expression patterns. Biological processes, thus, need precise temporal and spatial coordination of gene activity. Regulation of the fate of messenger RNA plays a crucial role in this context. In the present review, the current knowledge related to the role of RNA-binding proteins in the whole mRNA life-cycle is summarized. This field opens up a new angle for understanding the importance of the post-transcriptional control of gene expression in cancer cells. The emerging role of non-classic RNA-binding proteins is highlighted. The goal of this review is to encourage readers to view, through the mRNA life-cycle, novel aspects of the molecular basis of cancer and the potential to develop RNA-based therapies.

KEYWORDS:

DNA and RNA-binding proteins; RNA regulon; cytoplasmic RNA granules; galectin-3; intrinsically disordered regions; low complexity disordered regions; mRNA fate; mRNA life-cycle; mRNA-binding domains; mRNA-binding proteins

PMID:
29495341
PMCID:
PMC5877511
DOI:
10.3390/ijms19030650
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center