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Int J Reprod Biomed (Yazd). 2017 Dec;15(12):803-806.

Successful pregnancy and live birth after intrauterine administration of autologous platelet-rich plasma in a woman with recurrent implantation failure: A case report.

Author information

1
Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
2
Research Center for Health Sciences, Hamadan University of Medical sciences, Hamadan, Iran.
3
Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.
4
Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Abstract

Background:

Platelets contain a significant amount of growth factors that have positive effects on local tissue repair and endometrial receptivity.

Case:

Here we present a 45-yr-old woman with primary infertility and two failed in vitro fertilization (IVF) cycles who was candidate to receive donor eggs. Five consecutive frozen-thawed embryo transfer cycles with good quality embryos were performed within 2 yr. With the diagnosis of recurrent implantation failure (RIF), the patient was treated for improving endometrial receptivity with intrauterine administration of autologous platelet-rich plasma (PRP), 24 hr before embryo transfer. The patient gave birth to a healthy baby boy weighing 2350 gr in the cesarean section.

Conclusion:

Extensive literature search suggests that this is the first successful pregnancy after administration of PRP in a woman with RIF. Local administration of PRP before embryo transfer may play a vital role in successful implantation .

KEYWORDS:

Assisted reproductive technology; Embryo implantation; Embryo transfer; Platelet-rich plasma; Pregnancy outcome; Recurrent implantation failure

PMID:
29492478
PMCID:
PMC5816241

Conflict of interest statement

The authors declare that they have no conflict of interest.

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