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Sleep Med Rev. 2018 Oct;41:113-132. doi: 10.1016/j.smrv.2018.01.008. Epub 2018 Feb 5.

Slow-wave sleep: From the cell to the clinic.

Author information

1
Université Paris Descartes, Sorbonne Paris Cité, Équipe d'accueil VIgilance FAtigue SOMmeil (VIFASOM) EA 7330, France; Université Paris Descartes, Sorbonne Paris Cité, APHP, HUPC, Hôtel Dieu, Centre du Sommeil et de la Vigilance, Paris, France. Electronic address: damien.leger@aphp.fr.
2
Université Paris Descartes, Sorbonne Paris Cité, Équipe d'accueil VIgilance FAtigue SOMmeil (VIFASOM) EA 7330, France; Institut de Recherche Biomédicale des Armées (IRBA), Brétigny-sur-Orge, France; Rythm SAS, Paris, France. Electronic address: eden.dbm@gmail.com.
3
Université Paris Descartes, Sorbonne Paris Cité, Équipe d'accueil VIgilance FAtigue SOMmeil (VIFASOM) EA 7330, France; Institut de Recherche Biomédicale des Armées (IRBA), Brétigny-sur-Orge, France.
4
Université Paris Descartes, Sorbonne Paris Cité, Équipe d'accueil VIgilance FAtigue SOMmeil (VIFASOM) EA 7330, France; Université Paris Descartes, Sorbonne Paris Cité, APHP, HUPC, Hôtel Dieu, Centre du Sommeil et de la Vigilance, Paris, France.
5
Team Memory, Oscillations and Brain states (MOBs), Brain Plasticity Unit, CNRS, ESPCI Paris, PSL Research University, Paris, France.

Abstract

In recent decades, increasing evidence has positioned slow-wave sleep (SWS) as a major actor in neurophysiological phenomena such as glucose metabolism, hormone release, immunity and memory. This proposed role for SWS, coupled with observations of impaired SWS in several pathologies as well as in aging, has led some researchers to implement methods that could specifically enhance SWS. This review aims to gather the current knowledge extending from the cell to the clinic, in order to construct an overview of what is currently known about so-called SWS. We slowly expand the view from the molecular processes underlying SWS to the cell unit and assembly to cortical manifestations. We then describe its role in physiology and cognition to finally assess its association with clinical aspects. Finally, we address practical considerations for several techniques that could be used to manipulate SWS, in order to improve our understanding of SWS and possibly help the development of treatments for SWS clinical disorders.

KEYWORDS:

Deep sleep; EEG; K-complex; Memory consolidation; NREM; SO; SWA; SWS; Sleep

PMID:
29490885
DOI:
10.1016/j.smrv.2018.01.008
[Indexed for MEDLINE]

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