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PLoS One. 2018 Feb 28;13(2):e0190556. doi: 10.1371/journal.pone.0190556. eCollection 2018.

Regional cerebral effects of ketone body infusion with 3-hydroxybutyrate in humans: Reduced glucose uptake, unchanged oxygen consumption and increased blood flow by positron emission tomography. A randomized, controlled trial.

Author information

1
Department of Internal Medicine and Endocrinology, Aarhus University Hospital, Aarhus, Denmark.
2
Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.
3
Department of Nuclear Medicine and PET Center, Aarhus University Hospital, Aarhus, Denmark.
4
Section for Forensic Chemistry, Department of Forensic Medicine, Aarhus University Hospital, Aarhus, Denmark.
5
Centre of Functionally Integrative Neuroscience (CFIN) and MINDLab, Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.
6
Institute of Biomedicine, Aarhus University, Aarhus, Denmark.
7
Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark.

Abstract

Ketone bodies are neuroprotective in neurological disorders such as epilepsy. We randomly studied nine healthy human subjects twice-with and without continuous infusion of 3-hydroxybutyrate-to define potential underlying mechanisms, assessed regionally (parietal, occipital, temporal, cortical grey, and frontal) by PET scan. During 3-hydroxybutyrate infusions concentrations increased to 5.5±0.4 mmol/l and cerebral glucose utilisation decreased 14%, oxygen consumption remained unchanged, and cerebral blood flow increased 30%. We conclude that acute 3-hydroxybutyrate infusion reduces cerebral glucose uptake and increases cerebral blood flow in all measured brain regions, without detectable effects on cerebral oxygen uptake though oxygen extraction decreased. Increased oxygen supply concomitant with unchanged oxygen utilisation may contribute to the neuroprotective effects of ketone bodies.

PMID:
29489818
PMCID:
PMC5830038
DOI:
10.1371/journal.pone.0190556
[Indexed for MEDLINE]
Free PMC Article

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