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Vet J. 2018 Mar;233:41-48. doi: 10.1016/j.tvjl.2017.12.025. Epub 2018 Jan 3.

African swine fever: A re-emerging viral disease threatening the global pig industry.

Author information

1
The Pirbright Institute, Pirbright, Woking, Surrey GU24 0NF, UK.
2
The Pirbright Institute, Pirbright, Woking, Surrey GU24 0NF, UK. Electronic address: linda.dixon@pirbright.ac.uk.

Abstract

African swine fever (ASF) recently has spread beyond sub-Saharan Africa to the Trans-Caucasus region, parts of the Russian Federation and Eastern Europe. In this new epidemiological scenario, the disease has similarities, but also important differences, compared to the situation in Africa, including the substantial involvement of wild boar. A better understanding of this new situation will enable better control and prevent further spread of disease. In this article, these different scenarios are compared, and recent information on the pathogenesis of ASF virus strains, the immune response to infection and prospects for developing vaccines is presented. Knowledge gaps and the prospects for future control are discussed.

KEYWORDS:

African swine fever; Control; Epidemiology; Immune responses; Pathogenesis; Vaccination

PMID:
29486878
PMCID:
PMC5844645
DOI:
10.1016/j.tvjl.2017.12.025
[Indexed for MEDLINE]
Free PMC Article

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