Format

Send to

Choose Destination
J Eur Acad Dermatol Venereol. 2018 May;32(5):820-824. doi: 10.1111/jdv.14894. Epub 2018 Mar 23.

Insulin resistance in hidradenitis suppurativa: a case-control study.

Author information

1
Division of Dermatology, Hospital Universitario Marques de Valdecilla, IDIVAL, University of Cantabria, Santander, Cantabria, Spain.
2
Division of Internal Medicine, Hospital Universitario Marques de Valdecilla, IDIVAL, University of Cantabria, Santander, Cantabria, Spain.
3
Division of Rheumatology, Hospital Comarcal, Laredo, Cantabria, Spain.
4
Division of Medical Laboratory, Hospital Universitario Marques de Valdecilla, IDIVAL, University of Cantabria, Santander, Cantabria, Spain.
5
Division of Rheumatology, Hospital Universitario Marques de Valdecilla, IDIVAL, University of Cantabria, Santander, Cantabria, Spain.
6
Division of Pathology, Hospital Universitario Marques de Valdecilla, IDIVAL, University of Cantabria, Santander, Cantabria, Spain.

Abstract

BACKGROUND:

The association between chronic inflammatory diseases, such as rheumatoid arthritis and psoriasis, and insulin resistance (IR) has been well established. Hidradenitis suppurativa (HS) is a chronic inflammatory cutaneous disease that affects the apocrine gland-bearing areas of the body.

OBJECTIVE:

We aimed to determine the prevalence of IR in patients with HS.

METHODS:

This cross-sectional, case-control study enrolled 137 subjects, 76 patients with HS and 61 age- and gender-matched controls. Demographic data, clinical examination of HS patients, anthropometric measures, cardiovascular risk factors and laboratory studies were recorded. The homeostasis model assessment of IR (HOMA-IR) was calculated in all participants by measuring fasting plasma glucose and insulin levels.

RESULTS:

The median (IQR) HOMA-IR value in HS patients was significantly higher [2.0 (1.0-3.6)] than in controls [1.5 (0.9-2.3)] (P = 0.01). The prevalence of IR was significantly higher in cases (43.4%) compared with controls (16.4%) (P = 0.001). In the linear regression multivariable analysis after adjusting for age, sex and body mass index (BMI), HS remained as a significant factor for a higher HOMA-IR [2.51 (0.18) vs 1.92(0.21); P = 0.04]. The HOMA-IR value and the prevalence of IR did not differ significantly among HS patients grouped by severity of the disease.

CONCLUSION:

Our results show an increased frequency of IR in HS. Thus, we suggest HS patients to be evaluated for IR and managed accordingly.

Comment in

PMID:
29485215
DOI:
10.1111/jdv.14894
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center