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Nat Rev Urol. 2018 May;15(5):309-319. doi: 10.1038/nrurol.2018.14. Epub 2018 Feb 27.

Position paper: Rationale for the treatment of children with CCSK in the UMBRELLA SIOP-RTSG 2016 protocol.

Author information

1
Department of Paediatric Oncology, Princess Máxima Center for Paediatric Oncology, Utrecht, Netherlands.
2
Department of Paediatric Haematology and Oncology, Erasmus MC - Sophia Children's Hospital, Rotterdam, Netherlands.
3
Department of Paediatric Haematology and Oncology, Saarland University, Homburg, Germany.
4
Department of Haematology and Paediatric Onco-Haematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
5
Department of Paediatrics, Centre Léon Bérard, Lyon, France.
6
Department of Paediatric Oncology, Hospital Universitario Virgen del Rocío, Seville, Spain.
7
Department of Emergency Medicine, Medical University of Wroclaw and Department of Paediatric Surgery, Marciniak Hospital, Wroclaw, Poland.
8
Department of Radiotherapy and Radiation Oncology, Saarland University, Homburg, Germany.
9
Department of Radiation Oncology, Utrecht University Medical Center, Utrecht, Netherlands.
10
Department of Pathology, Sidra Medicine, Sidra Hospital, Qatar Foundation, Doha, Qatar.
11
Kiel Paediatric Tumour Registry, Department of Paediatric Pathology, University Schleswig-Holstein, Kiel, Germany.
12
Department of Pathology, Hopitaux Universitaires Est Parisien, Trousseau La Roche-Guyon, Paris, France.
13
Department of Radiology, Academic Medical Center (AMC), Amsterdam, Netherlands.
14
Instituto Nacional do Cancer, Paediatric Haematology and Oncology Program, Rio de Janeiro, Brazil.
15
Department of Paediatric and Adolescent Oncology, University College Hospital, Bloomsbury, London, UK.
16
Department of Statistics, Netherlands Cancer Institute (NKI-AvL), Amsterdam, Netherlands.
17
Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, University College, London, UK.

Abstract

The International Society of Paediatric Oncology-Renal Tumour Study Group (SIOP-RTSG) has developed a new protocol for the diagnosis, treatment, and follow-up monitoring of childhood renal tumours - the UMBRELLA SIOP-RTSG 2016 protocol (the UMBRELLA protocol). This protocol has been designed to continue international collaboration in the treatment of childhood renal tumours and will be implemented in over 50 different countries. Clear cell sarcoma of the kidney, which is a rare paediatric renal tumour that most commonly occurs in children between 2 and 4 years of age, is specifically addressed in the UMBRELLA protocol.

PMID:
29485128
DOI:
10.1038/nrurol.2018.14
[Indexed for MEDLINE]

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