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Nat Plants. 2018 Mar;4(3):148-151. doi: 10.1038/s41477-018-0115-z. Epub 2018 Feb 26.

Precision genome engineering through adenine and cytosine base editing.

Kim JS1,2.

Author information

1
Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea. jskim01@snu.ac.kr.
2
Department of Chemistry, Seoul National University, Seoul, Republic of Korea. jskim01@snu.ac.kr.

Abstract

Adenine base editors (ABEs), composed of an engineered deaminase and a catalytically impaired CRISPR-Cas9 variant, are powerful new tools for targeted base editing in cells and organisms. Together with cytosine base editors (CBEs), ABEs enable single-nucleotide conversions cleanly, efficiently and reversibly without double-stranded DNA cleavage, advancing genome editing in a new dimension.

PMID:
29483683
DOI:
10.1038/s41477-018-0115-z
[Indexed for MEDLINE]

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