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J Minim Access Surg. 2018 Feb 27. doi: 10.4103/jmas.JMAS_217_17. [Epub ahead of print]

Changes of serum and peritoneal inflammatory mediators in laparoscopic radical resection for right colon carcinoma.

Author information

1
Department of General Surgery, First People's Hospital of Changshu City, Changshu Hospital Affiliated to Soochow University, Changshu, China.
2
Department of Colorectal Surgery, Second Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province, China.

Abstract

Objective:

The objective of this study is to investigate the effects of laparoscopic and open operation on serum and peritoneal inflammatory mediators in patients with right colon carcinoma.

Patients and Methods: :

A total of 100 patients were randomly divided into laparoscopic group (n = 50) and open group (n = 50). The age, sex, operation time, operation blood loss, post-operative Dukes stage, time to first passage of flatus and post-operative hospital stay were recorded. The levels of hypersensitive C reactive protein (hsCRP) and tumour necrosis factor-α (TNF-α) in serum and abdominal exudate were measured by ELISA at the time of pre-operative 2 h and post-operative 6 h and 24 h.

Results:

There was no significant difference in age, sex, Dukes stage and pre-operative inflammatory mediators between the two groups (P > 0.05). The operation time, intraoperative blood loss, time to first passage of flatus and post-operative hospital stay were significantly better in laparoscopic group than those in open operation group. At 6 h and 24 h after operation, the levels of hsCRP and TNF-α in serum and abdominal exudate in laparoscopic group were significantly lower than those in open operation group.

Conclusions:

Laparoscopic surgery for the treatment of right colon carcinoma has the advantages of fewer traumas, less systemic and local inflammatory response, rapider post-operative recovery and shorter hospital stay. It is worthy of clinical application.

KEYWORDS:

Inflammatory mediators; laparoscopy; right colon carcinoma

PMID:
29483379
DOI:
10.4103/jmas.JMAS_217_17
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