Format

Send to

Choose Destination
Reprod Biol Endocrinol. 2018 Feb 27;16(1):16. doi: 10.1186/s12958-018-0334-1.

Proteomic profile of human spermatozoa in healthy and asthenozoospermic individuals.

Author information

1
Department of Clinical Laboratory, Ningbo Municipal Hospital of Traditional Chinese Medicine, Ningbo, 315000, China.
2
Department of Clinical Laboratory, Ningbo Municipal Hospital of Traditional Chinese Medicine, Ningbo, 315000, China. cxd0319@163.com.

Abstract

Asthenozoospermia is considered as a common cause of male infertility and characterized by reduced sperm motility. However, the molecular mechanism that impairs sperm motility remains unknown in most cases. In the present review, we briefly reviewed the proteome of spermatozoa and seminal plasma in asthenozoospermia and considered post-translational modifications in spermatozoa of asthenozoospermia. The reduction of sperm motility in asthenozoospermic patients had been attributed to factors, for instance, energy metabolism dysfunction or structural defects in the sperm-tail protein components and the differential proteins potentially involved in sperm motility such as COX6B, ODF, TUBB2B were described. Comparative proteomic analysis open a window to discover the potential pathogenic mechanisms of asthenozoospermia and the biomarkers with clinical significance.

KEYWORDS:

Asthenozoospermia; Infertility; Proteome; Sperm motility; Spermatozoa

PMID:
29482568
PMCID:
PMC5828484
DOI:
10.1186/s12958-018-0334-1
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center