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Cereb Cortex. 2018 May 1;28(5):1866-1881. doi: 10.1093/cercor/bhy035.

Directed Interaction Between Monkey Premotor and Posterior Parietal Cortex During Motor-Goal Retrieval from Working Memory.

Author information

1
German Primate Center, Cognitive Neuroscience Lab, Kellnerweg 4, 37077 Göttingen, Germany.
2
Bernstein Center for Computational Neuroscience, Göttingen, Germany.
3
Faculty of Biology and Psychology, Georg-August-Universität, Göttingen, Germany.

Abstract

Goal-directed behavior requires cognitive control of action, putatively by means of frontal-lobe impact on posterior brain areas. We investigated frontoparietal directed interaction (DI) in monkeys during memory-guided rule-based reaches, to test if DI supports motor-goal selection or working memory (WM) processes. We computed DI between the parietal reach region (PRR) and dorsal premotor cortex (PMd) with a Granger-causality measure of intracortical local field potentials (LFP). LFP mostly in the beta (12-32 Hz) and low-frequency (f≤10Hz) ranges contributed to DI. During movement withholding, beta-band activity in PRR had a Granger-causal effect on PMd independent of WM content. Complementary, low-frequency PMd activity had a transient Granger-causing effect on PRR specifically during WM retrieval of spatial motor goals, while no DI was associated with preliminary motor-goal selection. Our results support the idea that premotor and posterior parietal cortices interact functionally to achieve cognitive control during goal-directed behavior, in particular, that frontal-to-parietal interaction occurs during retrieval of motor-goal information from spatial WM.

PMID:
29481586
PMCID:
PMC5907360
DOI:
10.1093/cercor/bhy035
[Indexed for MEDLINE]
Free PMC Article

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