Format

Send to

Choose Destination
Elife. 2018 Feb 26;7. pii: e28569. doi: 10.7554/eLife.28569.

A neural circuit for gamma-band coherence across the retinotopic map in mouse visual cortex.

Author information

1
Department of Molecular and Cell Biology, University of California, Berkeley, United States.
2
Helen Wills Neuroscience Institute, University of California, Berkeley, United States.

Abstract

Cortical gamma oscillations have been implicated in a variety of cognitive, behavioral, and circuit-level phenomena. However, the circuit mechanisms of gamma-band generation and synchronization across cortical space remain uncertain. Using optogenetic patterned illumination in acute brain slices of mouse visual cortex, we define a circuit composed of layer 2/3 (L2/3) pyramidal cells and somatostatin (SOM) interneurons that phase-locks ensembles across the retinotopic map. The network oscillations generated here emerge from non-periodic stimuli, and are stimulus size-dependent, coherent across cortical space, narrow band (30 Hz), and depend on SOM neuron but not parvalbumin (PV) neuron activity; similar to visually induced gamma oscillations observed in vivo. Gamma oscillations generated in separate cortical locations exhibited high coherence as far apart as 850 μm, and lateral gamma entrainment depended on SOM neuron activity. These data identify a circuit that is sufficient to mediate long-range gamma-band coherence in the primary visual cortex.

KEYWORDS:

digital micromirror device; gamma oscillations; mouse; neuroscience; optogenetics; parvalbumin neurons; somatostatin neurons; visual cortex

PMID:
29480803
PMCID:
PMC5826269
DOI:
10.7554/eLife.28569
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for eLife Sciences Publications, Ltd Icon for PubMed Central
Loading ...
Support Center