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World J Microbiol Biotechnol. 2018 Feb 26;34(3):41. doi: 10.1007/s11274-018-2425-8.

Recent advances in microbial production of mannitol: utilization of low-cost substrates, strain development and regulation strategies.

Zhang M1, Gu L1, Cheng C1, Ma J1, Xin F1, Liu J2, Wu H1,3,4, Jiang M5,6,7.

Author information

1
College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Puzhu South Road 30#, Nanjing, 211800, People's Republic of China.
2
Institute of Chemical Industry of Forest Products, Nanjing, 210042, People's Republic of China.
3
State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Puzhu South Road 30#, Nanjing, 211800, People's Republic of China.
4
The Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Puzhu South Road 30#, Nanjing, 211800, People's Republic of China.
5
College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Puzhu South Road 30#, Nanjing, 211800, People's Republic of China. bioengine@njtech.edu.cn.
6
State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Puzhu South Road 30#, Nanjing, 211800, People's Republic of China. bioengine@njtech.edu.cn.
7
The Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Puzhu South Road 30#, Nanjing, 211800, People's Republic of China. bioengine@njtech.edu.cn.

Abstract

Mannitol has been widely used in fine chemicals, pharmaceutical industries, as well as functional foods due to its excellent characteristics, such as antioxidant protecting, regulation of osmotic pressure and non-metabolizable feature. Mannitol can be naturally produced by microorganisms. Compared with chemical manufacturing, microbial production of mannitol provides high yield and convenience in products separation; however the fermentative process has not been widely adopted yet. A major obstacle to microbial production of mannitol under industrial-scale lies in the low economical efficiency, owing to the high cost of fermentation medium, leakage of fructose, low mannitol productivity. In this review, recent advances in improving the economical efficiency of microbial production of mannitol were reviewed, including utilization of low-cost substrates, strain development for high mannitol yield and process regulation strategies for high productivity.

KEYWORDS:

Fermentation; Mannitol; Metabolic flux; Regulation; Strain development

PMID:
29480337
DOI:
10.1007/s11274-018-2425-8
[Indexed for MEDLINE]

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