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Transl Psychiatry. 2018 Feb 26;8(1):47. doi: 10.1038/s41398-018-0094-x.

Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-amyloid burden.

Author information

1
Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, 6027, WA, Australia.
2
Sir James McCusker Alzheimer's Disease Research Unit, Hollywood Private Hospital, Perth, 6009, WA, Australia.
3
Collaborative Genomics Group, Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, 6027, WA, Australia.
4
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, 3052, VIC, Australia.
5
Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, 3084, VIC, Australia.
6
School of Psychology and Exercise Science, Murdoch University, Murdoch, 6150, WA, Australia.
7
Co-operative Research Centre for Mental Health, Carlton, VIC, Australia.
8
School of Psychological Science, University of Western Australia, Crawley, 6009, WA, Australia.
9
Department of Biomedical Sciences, Macquarie University, North Ryde, 2113, NSW, Australia.
10
Academic Unit for Psychiatry of Old Age, St. Vincent's Health, The University of Melbourne, Kew, 3101, VIC, Australia.
11
National Ageing Research Institute, Parkville, 3052, VIC, Australia.
12
CogState Ltd., Melbourne, 3000, VIC, Australia.
13
CSIRO Health and Biosecurity/Australian e-Health Research Centre, Herston, 4029, QLD, Australia.
14
Collaborative Genomics Group, Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, 6027, WA, Australia. s.laws@ecu.edu.au.
15
Co-operative Research Centre for Mental Health, Carlton, VIC, Australia. s.laws@ecu.edu.au.
16
School of Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, 6102, WA, Australia. s.laws@ecu.edu.au.

Abstract

The glymphatic system is postulated to be a mechanism of brain Aβ-amyloid clearance and to be most effective during sleep. Ablation of the astrocytic end-feet expressed water-channel protein, Aquaporin-4, in mice, results in impairment of this clearance mechanism and increased brain Aβ-amyloid deposition, suggesting that Aquaporin-4 plays a pivotal role in glymphatic function. Currently there is a paucity of literature regarding the impact of AQP4 genetic variation on sleep, brain Aβ-amyloid burden and their relationship to each other in humans. To address this a cross-sectional observational study was undertaken in cognitively normal older adults from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. Genetic variants in AQP4 were investigated with respect to self-reported Pittsburgh Sleep Quality Index sleep parameters, positron emission tomography derived brain Aβ-amyloid burden and whether these genetic variants moderated the sleep-Aβ-amyloid burden relationship. One AQP4 variant, rs72878776, was associated with poorer overall sleep quality, while several SNPs moderated the effect of sleep latency (rs491148, rs9951307, rs7135406, rs3875089, rs151246) and duration (rs72878776, rs491148 and rs2339214) on brain Aβ-amyloid burden. This study suggests that AQP4 genetic variation moderates the relationship between sleep and brain Aβ-amyloid burden, which adds weight to the proposed glymphatic system being a potential Aβ-amyloid clearance mechanism and suggests that AQP4 genetic variation may impair this function. Further, AQP4 genetic variation should be considered when interpreting sleep-Aβ relationships.

PMID:
29479071
PMCID:
PMC5865132
DOI:
10.1038/s41398-018-0094-x
[Indexed for MEDLINE]
Free PMC Article

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