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Trends Immunol. 2018 May;39(5):380-392. doi: 10.1016/j.it.2018.01.012. Epub 2018 Feb 22.

Lipid Droplets as Immune Modulators in Myeloid Cells.

Author information

1
Department of Radiation Oncology, Radiotherapy & OncoImmunology Laboratory, Radboud Institute for Molecular Life Sciences, Radboud UMC, Geert Grooteplein Zuid 32, 6525 GA, Nijmegen, The Netherlands; Department of Anesthesiology, Pain and Palliative Medicine, Radboud UMC, Geert Grooteplein 10, 6525 GA Nijmegen, The Netherlands.
2
Department of Radiation Oncology, Radiotherapy & OncoImmunology Laboratory, Radboud Institute for Molecular Life Sciences, Radboud UMC, Geert Grooteplein Zuid 32, 6525 GA, Nijmegen, The Netherlands.
3
Department of Radiation Oncology, Radiotherapy & OncoImmunology Laboratory, Radboud Institute for Molecular Life Sciences, Radboud UMC, Geert Grooteplein Zuid 32, 6525 GA, Nijmegen, The Netherlands. Electronic address: Gosse.Adema@radboudumc.nl.

Abstract

Lipid droplets (LDs) were initially described as fat storage organelles in adipocytes, but are increasingly recognized as dynamic players in lipid metabolism, with important roles not only in diseases such as diabetes and cancer, but also in immune regulation. Alterations in immune cell function, such as myeloid cell activation, are connected to profound changes in LD numbers and LD protein composition. Thus, these organelles appear to be essential to metabolically support immune responses, and have a vital role in antigen crosspresentation, interferon (IFN) responses, production of inflammatory mediators, and pathogen clearance. Here, we review recent studies that report on the role of LDs in the modulation of immune cell function, primarily focusing on myeloid cells, such as macrophages and dendritic cells (DCs).

PMID:
29478771
DOI:
10.1016/j.it.2018.01.012

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