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Biomed Pharmacother. 2018 Apr;100:486-494. doi: 10.1016/j.biopha.2018.02.019. Epub 2018 Feb 23.

Bavachin induces the apoptosis of multiple myeloma cell lines by inhibiting the activation of nuclear factor kappa B and signal transducer and activator of transcription 3.

Author information

1
Division of Pharmacotherapy, Kindai University School of Pharmacy, Kowakae, Higashi-Osaka, Osaka, Japan.
2
Department of Food Science and Nutrition, Kindai University School of Agriculture, Nara, Nara, Japan.
3
Department of Surgery, Kindai University School of Medicine, Osakasayama, Osaka, Japan.
4
Department of Pathology, Kindai University School of Medicine, Osakasayama, Osaka, Japan.
5
Division of Pharmacotherapy, Kindai University School of Pharmacy, Kowakae, Higashi-Osaka, Osaka, Japan. Electronic address: nishida@phar.kindai.ac.jp.

Abstract

Bavachin is a phytoestrogen purified from natural herbal plants such as Psoralea corylifolia. In this study, we examined the effect of bavachin in multiple myeloma (MM) cell lines. We found that bavachin decreased the viability of MM cell lines, but was not cytotoxic towards normal cells. It inhibited the activation of nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3). Furthermore, bavachin increased the expression of p53 and NOXA, and decreased the expression of X-linked inhibitor of apoptosis protein (XIAP), survivin, B cell lymphoma-extra large (Bcl-xL), and Bcl-2. Additionally, bavachin induced apoptosis by the activation of caspase-3 and caspase-9, implicating the involvement of the mitochondrial pathway. Our results suggest that bavachin induces apoptosis through the inhibition of NF-κB and STAT3 activation in MM cell lines. Most importantly, few NF-κB and STAT3 inhibitors with high efficiency, specificity, and safety are currently available for clinical cancer therapy. Hence, bavachin, which targets NF-κB and STAT3, is a potential anticancer agent for the treatment of MM.

KEYWORDS:

Bavachin; Multiple myeloma (MM); Nuclear factor kappa B (NF-κB); Signal transducer and activator of transcription 3 (STAT3)

PMID:
29477912
DOI:
10.1016/j.biopha.2018.02.019
[Indexed for MEDLINE]

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