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Food Chem Toxicol. 2018 Apr;114:270-277. doi: 10.1016/j.fct.2018.02.046. Epub 2018 Feb 22.

Renal and hepatic effects following neonatal exposure to low doses of Bisphenol-A and 137Cs.

Author information

1
Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, Reus, Spain.
2
Physiology Unit, School of Medicine, IISPV, Universitat Rovira i Virgili, Reus, Spain; Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, Reus, Spain.
3
Research Unit on Lipids and Atherosclerosis, Sant Joan University Hospital, IISPV, Universitat Rovira i Virgili, Reus, Spain.
4
Physiology Unit, School of Medicine, IISPV, Universitat Rovira i Virgili, Reus, Spain; Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, Reus, Spain. Electronic address: mvictoria.linares@urv.cat.

Abstract

137-Cesium (137Cs) is one of the most important distributed radionuclides after a nuclear accident. Humans are usually co-exposed to various environmental toxicants, being Bisphenol-A (BPA) one of them. Exposure to IR and BPA in early life is of major concern, due to the higher vulnerability of developing organs. We evaluate the renal and hepatic effects of low doses of ionizing radiation (IR) and BPA. Sixty male mice (C57BL/6J) were randomly assigned to six experimental groups (n=10) and received a single subcutaneous dose of 0.9% saline solution, 137Cs and/or BPA on postnatal day 10: control, BPA (25 μg/kgbw), Cs4000 (4000 Bq 137Cs/kgbw), Cs8000 (8000 Bq 137Cs/kgbw), BPA/Cs4000 and BPA/Cs8000. At the age of two months, urines (24h) and blood samples were collected from animals of each group to determine biochemical parameters. Finally, kidneys and liver were removed to quantify DNA damage (8-OHdG), as well as to determine CYP1A2 mRNA expression. Data suggest that both BPA and 137Cs induced renal and liver damage evidenced by oxidative stress. However, when there is a co-exposure, it seems that there are compensatory mechanisms that may reverse the damage induced by each toxic itself. Notwithstanding, more studies are necessary to better understand the synergistic mechanisms behind.

PMID:
29477810
DOI:
10.1016/j.fct.2018.02.046
[Indexed for MEDLINE]

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